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首页> 外文期刊>Life sciences >Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide.
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Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide.

机译：吗啡-3-葡糖醛酸对兴奋性行为的脑区域特异性研究。

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This study was designed to determine in rats whether morphine-3-glucuronide (M3G) produces its neuro-excitatory effects most potently in the ventral hippocampus (as has been reported previously for subanalgesic doses of opioid peptides). Guide cannulae were implanted into one of seven regions of the rat brain: lateral ventricle; ventral, CA1 and CA2-CA3 regions of the hippocampus; amygdala; striatum or cortex. After a 7 day recovery period, rats received intracerebral injections of (i) M3G (1.1 or 11 nmol) (ii) DADLE ([D-Ala2,D-Leu5]enkephalin), (45 nmol, positive controls) or (iii) vehicle (deionised water), and behavioral excitation was quantified over 80 min. High-dose M3G (11 nmol) evoked behavioral excitation in all brain regions but the onset, severity and duration of these effects varied considerably among brain regions. By contrast, low-dose M3G (1.1 nmol) evoked excitatory behaviors only when administered into the ventral hippocampus and the amygdala, with the most potent effects being observed in the ventral hippocampus. Prior administration of the nonselective opioid antagonists, naloxone and beta-funaltrexamine into the ventral hippocampus, markedly attenuated low-dose M3G's excitatory effects but did not significantly alter levels of excitation evoked by high-dose M3G. Naloxone given 10 min after M3G (1.1 or 11 nmol) did not significantly attenuate behavioral excitation. Thus, M3G's excitatory behavioral effects occur most potently in the ventral hippocampus as reported previously for subanalgesic doses of opioid peptides, and appear to be mediated through at least two mechanisms, one possibly involving excitatory opioid receptors and the other, non-opioid receptors.
机译：这项研究旨在确定大鼠吗啡-3-葡糖醛酸内酯（M3G）是否在腹侧海马中最有效地产生其神经兴奋作用（如先前有关镇痛剂量的阿片样肽的报道）。引导套管被植入大鼠大脑七个区域之一：侧脑室;海马腹侧，CA1和CA2-CA3区域;杏仁核纹状体或皮质。恢复期7天后，大鼠接受脑内注射（i）M3G（1.1或11 nmol）（ii）DADLE（[D-Ala2，D-Leu5]脑啡肽），（45 nmol，阳性对照）或（iii）载体（去离子水），并在80分钟内量化行为激励。大剂量的M3G（11 nmol）在所有大脑区域引起了行为兴奋，但是这些效应的发作，严重性和持续时间在大脑区域之间差异很大。相比之下，低剂量的M3G（1.1 nmol）仅在腹侧海马和杏仁核中引起兴奋行为，在腹侧海马中观察到最有效的作用。先前在腹侧海马中施用非选择性阿片类拮抗剂，纳洛酮和β-去甲曲沙明显着减弱了小剂量M3G的兴奋作用，但并未显着改变大剂量M3G引起的兴奋水平。 M3G（1.1或11 nmol）后10分钟给予纳洛酮不会显着减弱行为兴奋。因此，M3G的兴奋性行为效应最有效地发生在腹侧海马区，如先前有关镇痛剂量的阿片样肽的报道，并且似乎是通过至少两种机制介导的，一种可能涉及兴奋性阿片受体，而另一种是非阿片受体。

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