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首页> 外文期刊>Life sciences >Capsaicin protects against ethanol-induced oxidative injury in the gastric mucosa of rats.
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Capsaicin protects against ethanol-induced oxidative injury in the gastric mucosa of rats.

机译：辣椒素可防止乙醇引起的大鼠胃粘膜氧化损伤。

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摘要

In this study, we investigated the protective effects of capsaicin on gastric mucosal oxidative damage induced by ethanol. Sprague Dawley rats intragastrically received 0.5-10 mg/kg, BW capsaicin or vehicle; 30 min later gastric lesions were induced by intragastric administration of absolute ethanol. Lipid peroxidation was estimated by measuring thiobarbituric acid reactive substances in gastric mucosa. Myeloperoxidase activity, a marker enzyme of polymorphonuclear leukocytes for tissue inflammation, was also measured in the gastric mucosa. The expression level of cyclooxygenase-2, which increases in inflammatory region, was determined by Western blot analysis. Capsaicin significantly suppressed gastric haemorrhagic erosions induced by ethanol. Capsaicin inhibited lipid peroxidation and myeloperoxidase activity in ethanol-induced gastric mucosal lesion in a dose-dependent manner. Capsaicin also inhibited the expression of cyclooxygenase-2 in the gastric mucosal lesion. The gastroprotective activity of capsaicin on the ethanol-induced oxidative damage may be important for chemoprevention.
机译：在这项研究中，我们调查了辣椒素对乙醇诱导的胃黏膜氧化损伤的保护作用。 Sprague Dawley大鼠在胃内接受0.5-10 mg / kg，BW辣椒素或赋形剂; 30分钟后，通过胃内施用无水乙醇诱发胃部病变。通过测量胃粘膜中的硫代巴比妥酸反应性物质来估计脂质过氧化。还在胃粘膜中测量了髓过氧化物酶活性，该酶是用于组织炎症的多形核白细胞的标志物酶。通过Western印迹分析确定在炎症区域增加的环氧合酶-2的表达水平。辣椒素可显着抑制乙醇引起的胃出血。辣椒素以剂量依赖的方式抑制乙醇诱导的胃粘膜病变中脂质过氧化和髓过氧化物酶活性。辣椒素还抑制胃粘膜病变中环氧合酶2的表达。辣椒素对乙醇诱导的氧化损伤的胃保护活性可能对化学预防很重要。

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