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首页> 外文期刊>Cell and Tissue Research >Ontogeny of reticular framework of white pulp and marginal zone in human spleen: immunohistochemical studies of fetal spleens from the 17th to 40th week of gestation.
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Ontogeny of reticular framework of white pulp and marginal zone in human spleen: immunohistochemical studies of fetal spleens from the 17th to 40th week of gestation.

机译：人类脾脏中白髓和边缘区的网状构架的个体发育：妊娠第17至40周胎儿脾脏的免疫组织化学研究。

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摘要

The antigenic heterogeneity of the reticular framework of the white pulp (WP) and marginal zone (MZ) is well documented in the human adult spleen. The ontogeny of the WP and MZ of human fetal spleens was examined with special reference to the heterogeneity of the reticular framework. In the spleen of the 17th gestational week (gw), alpha-smooth muscle actin (alpha-SMA)-positive reticulum cells were scattered around the arterioles. From the 20th to 23rd gw, alpha-SMA-positive reticulum cells increased in number and began to form a reticular framework. An accumulation of T and B lymphocytes occurred within the framework, and a primitive WP was observed around the arterioles. At the 24th gw, antigenic diversity of the reticular framework was observed, and T and B lymphocytes were segregated in the framework. T lymphocytes were sorted into the alpha-SMA-positive reticular framework, and the periarteriolar lymphoid sheath (PALS) was formed around the arteriole. B lymphocytes aggregated in eccentric portions to the PALS and formed the lymph follicle (LF). The reticular framework of the LF was alpha-SMA-negative. MZ appeared in the alpha-SMA-positive reticular framework around the WP at the 26th gw. The PALS, LF, and MZ developed with gestational time. The reticular framework of the PALS, LF, and MZ is thus heterogeneous in the fetal spleen, and the development of the heterogeneity is related to the ontogeny of the PALS, LF, and MZ.
机译：在成人脾脏中，白纸浆（WP）和边缘区（MZ）的网状构架的抗原异质性得到了充分的证明。检查人胎脾的WP和MZ的个体发育，并特别参考网状框架的异质性。在第17个孕周（gw）的脾脏中，α平滑肌肌动蛋白（alpha-SMA）阳性网状细胞散布在小动脉周围。从20到23 GW，α-SMA阳性网状细胞数量增加，并开始形成网状框架。 T和B淋巴细胞的积累发生在框架内，并且在小动脉周围观察到原始的WP。在第24 gw，观察到网状框架的抗原多样性，并且T和B淋巴细胞在框架中分离。将T淋巴细胞分选到alpha-SMA阳性网状框架中，并在小动脉周围形成小动脉周围淋巴样鞘（PALS）。 B淋巴细胞在PALS的偏心部分聚集并形成淋巴滤泡（LF）。 LF的网状构架为α-SMA阴性。 MZ出现在第26 gw WP附近的alpha-SMA阳性网状框架中。 PALS，LF和MZ随着妊娠时间的发展而发展。因此，PALS，LF和MZ的网状结构在胎儿脾中是异质的，异质性的发展与PALS，LF和MZ的个体发育有关。

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