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Immunopontentiating and antitumor activities of the purified polysaccharides from Phellodendron chinese SCHNEID

机译：黄柏多糖的免疫增强及其抗肿瘤活性。

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摘要

The polysaccharide fractions were isolated and purified from Phellodendron chinese SCHNEID, and antitumor activities were examined at dosages of 2, 5 and 10 mg/100 g. F-7 and F-8 showed the highest tumor inhibitory activities (inhibition ratio 96.4 and 98.2% in 2 mg/100 g), and in dose of 5 mg/100 g, the inhibitory ratios were 95.3 and 97.5%, respectively. Furthermore, 10 mg/100 g of intraperitoneal (i.p.) injection gave 97.3 and 98.7% of inhibition. In oral administration, the inhibitory activities were not markedly observed, indicating that the polysaccharides are directly acting to immune system. Also the polysaccharides increased the number of circulating blood leukocytes and total peritoneal exudate cells. Although implantation of tumor cells greatly decreased the productivity of antibody (antibody-mediated) and T lymphocyte reactivity (delayed-type) as 6.3 from 9.3 and 5.9 from 7.7, represented by the increase of footpad thickness, respectively. The polysaccharides elevated the reactivity of T lymphocyte in tumor-bearing mice, which were rapidly recovered by discontinuance of sample treatments. Especially, F-2, F-5, F-7 and F-8 remarkably recovered the decreased sensitivity. When the effects on thymidylate synthase (TS) and thymidine kinase (TK) activities were determined, TS activities in the F-2 and F-7-treated mice were markedly suppressed to 73.7% and 79.5% of that in the control (p < 0.01), while there was little difference in TK activity with a slight decrease in F-2 only. However, in i.p. injection, TS activities in the F-2, F-5, F-7 and F-8-treated mice were markedly suppressed to 83% to 85% of that in the control (p < 0.01). Furthermore, there were also significant differences in TK activities in F-2, F-5, F-7 and F-8-treated mice (p < 0.05). These results clearly indicated that the i.p. injection is much effective to suppress tumor growth than oral administration. (C) 2004 Elsevier Inc. All rights reserved.
机译：从黄柏SCHNEID中分离和纯化多糖级分，并以2、5和10mg / 100g的剂量检查其抗肿瘤活性。 F-7和F-8表现出最高的肿瘤抑制活性（在2 mg / 100 g中抑制率分别为96.4和98.2％），在5 mg / 100 g剂量中，抑制率分别为95.3和97.5％。此外，以10mg / 100g腹膜内（i.p.）注射产生97.3％和98.7％的抑制。在口服给药中，没有明显观察到抑制活性，表明多糖直接对免疫系统起作用。多糖还增加了循环血液白细胞和总腹膜渗出细胞的数量。尽管肿瘤细胞的植入大大降低了抗体（抗体介导的）和T淋巴细胞反应性（延迟型）的生产率，分别为9.3和9.3，分别为6.3和5.9，分别以脚垫厚度的增加为代表。多糖提高了荷瘤小鼠中T淋巴细胞的反应性，通过中断样品处理可以迅速恢复多糖的活性。特别是F-2，F-5，F-7和F-8可以显着降低灵敏度。确定对胸苷酸合酶（TS）和胸苷激酶（TK）活性的影响后，经F-2和F-7处理的小鼠的TS活性被显着抑制为对照组的73.7％和79.5％（p < 0.01），而TK活性差异不大，仅F-2略有下降。但是，在i.p.注射后，经F-2，F-5，F-7和F-8处理的小鼠的TS活性被显着抑制至对照组的83％至85％（p <0.01）。此外，在F-2，F-5，F-7和F-8处理的小鼠中TK活性也存在显着差异（p <0.05）。这些结果清楚地表明注射比口服给药更有效地抑制肿瘤生长。 （C）2004 Elsevier Inc.保留所有权利。

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