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Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats

机译：衰老影响Wistar大鼠海马，下丘脑和肾上腺的氧化状态

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The aging process is associated with cognitive impairment and dysregulation of the hypothalaimic-pituitary-adrenal (HPA) axis, as well as with oxidative stress. We determined some parameters of oxidative stress in homogenates of hippocampus, hypothalamus and adrenal glands from male 2-, 6- and 24-months-old Wistar rats. A significant age-dependent increase in the generation of free radicals was observed in hippocampus, hypothalamus and adrenal glands, as well as on lipid peroxidation in hippocampus and hypothalamus. The glutathione peroxidase (GPx) activity was significantly reduced in hypothalamus and hippocampus from 6-months-old rats; a decline on GPx and catalase activities in adrenal glands of 24-months-old animals was also present. Interestingly, a great decrease in total antioxidant capacity was found in all tissues tested. Reported findings support the idea that oxidative events participate on multiple neuroendocrine-metabolic impairments and suggest that the oxidative stress found in hippocampus, hypothalamus and adrenals might be associated with age-related physiological deficits. (c) 2005 Elsevier Inc. All rights reserved.
机译：衰老过程与认知障碍和下丘脑-垂体-肾上腺（HPA）轴失调以及氧化应激有关。我们确定了雄性2、6和24个月大的Wistar大鼠海马，下丘脑和肾上腺匀浆中氧化应激的一些参数。在海马，下丘脑和肾上腺，以及海马和下丘脑的脂质过氧化反应中，自由基产生的年龄均显着增加。 6个月大的大鼠下丘脑和海马的谷胱甘肽过氧化物酶（GPx）活性显着降低;在24个月大的动物的肾上腺中，GPx和过氧化氢酶活性也下降。有趣的是，在所有测试的组织中发现总抗氧化剂能力大大降低。报道的发现支持氧化事件参与多种神经内分泌-代谢损伤的想法，并暗示在海马，下丘脑和肾上腺中发现的氧化应激可能与年龄相关的生理缺陷有关。 （c）2005 Elsevier Inc.保留所有权利。

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