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首页> 外文期刊>Life sciences >Oral magnesium administration prevents vascular complications in STZ-diabetic rats.
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Oral magnesium administration prevents vascular complications in STZ-diabetic rats.

机译：口服镁可预防STZ糖尿病大鼠的血管并发症。

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Vascular disease is one of the complicating features of diabetes mellitus. Magnesium deficiency has recently been proposed as a novel factor implicated in the pathogenesis of diabetes complications. Several studies have indicated that hypertension in diabetic patients is an independent altered reaction of blood vessels to neurotransmitters and circulating hormones. Since magnesium has been proposed to decrease vascular sensitivity to vasoconstrictor agents, the present study was designed to determine whether chronic magnesium sulfate administration could prevent vascular complications of STZ-induced diabetes in rats. The animals were divided into six groups: two groups served as controls and received tap water for 8 weeks, while in the other four groups, made diabetic with a single IV injection of 40 mg/kg STZ, two groups treated with magnesium sulfate (10 g/L) added to the drinking water, and the other two groups received tap water only. After 8 weeks, in 3 groups (control, diabetic and Mg-treated), left common carotid artery was cannulated for continuous recording of blood pressure. All animals in these groups were decapitated and blood samples were drawn for glucose, Ca and Mg measurements. In the 3 remaining groups (again divided into control, diabetic and Mg-treated), the mesenteric vascular bed was perfused according to the McGregor method, and descending thoracic aortas were used for measurement of elasticity. In diabetic rats, plasma glucose was significantly increased and plasma magnesium was significantly decreased compared to controls and Mg-treated animals. Although plasma magnesium of Mg-treated animals increased significantly, it failed to reach to the magnesium level of the control group. Ca/Mg ratio was also increased compared to the control and Mg-treated animals. Mean arterial blood pressure in diabetics was significantly higher than control and Mg-treated rats. Similarly, there was a significant difference in mean arterial blood pressure of Mg-treated rats compared to control animals. Baseline perfusion pressure of diabetic group was significantly higher than control and Mg-treated groups with intact and denuded endothelium. Magnesium sulfate treatment decreased mean perfusion pressure of mesenteric vascular bed in intact and denuded endothelium in comparison with non-treated diabetic rats. There was a significant increase in passive tension in the aorta of diabetic rats compared to control and Mg-treated rats. However, there was no significant difference between Mg-treated and control rats. From the results of this study it may be concluded that magnesium could control STZ-induced diabetes and prevent its vascular complications.
机译：血管疾病是糖尿病的复杂特征之一。最近有人提出镁缺乏症是与糖尿病并发症的发病机制有关的新因素。几项研究表明，糖尿病患者的高血压是血管对神经递质和循环激素的独立改变的反应。由于已经提出镁可以降低血管对血管收缩药的敏感性，因此本研究旨在确定长期服用硫酸镁是否可以预防STZ诱导的糖尿病大鼠的血管并发症。将动物分为六组：两组作为对照组并接受自来水8周，而其他四组则通过单次静脉内注射40 mg / kg STZ患上糖尿病，两组分别用硫酸镁治疗（10 g / L）添加到饮用水中，其他两组仅接收自来水。 8周后，在3组（对照组，糖尿病组和Mg治疗组）中，对左颈总动脉进行插管以连续记录血压。将这些组中的所有动物斩首，抽取血样进行葡萄糖，钙和镁的测量。在剩下的3组中（再次分为对照组，糖尿病组和Mg治疗组），根据McGregor方法灌注肠系膜血管床，并用降胸主动脉测量弹性。与对照组和经Mg处理的动物相比，在糖尿病大鼠中，血浆葡萄糖显着增加，血浆镁显着减少。尽管用Mg处理过的动物的血浆镁含量显着增加，但仍未达到对照组的镁水平。与对照和经Mg处理的动物相比，Ca / Mg比也有所增加。糖尿病患者的平均动脉血压明显高于对照组和经Mg处理的大鼠。同样，与对照组相比，经Mg处理的大鼠的平均动脉血压存在显着差异。糖尿病组的基线灌注压显着高于对照组和完整和裸露内皮的镁治疗组。与未治疗的糖尿病大鼠相比，硫酸镁治疗降低了完整和裸露的内皮细胞的肠系膜血管床的平均灌注压力。与对照组和镁治疗的大鼠相比，糖尿病大鼠的主动脉被动张力显着增加。但是，用镁处理的大鼠和对照大鼠之间没有显着差异。从这项研究的结果可以得出结论，镁可以控制STZ诱导的糖尿病并预防其血管并发症。

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