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首页> 外文期刊>Life sciences >AGE-RELATED EFFECTS OF ALUMINUM INGESTION ON BRAIN ALUMINUM ACCUMULATION AND BEHAVIOR IN RATS
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AGE-RELATED EFFECTS OF ALUMINUM INGESTION ON BRAIN ALUMINUM ACCUMULATION AND BEHAVIOR IN RATS

机译：铝摄入对大鼠脑铝累积和行为的年龄影响

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Both aluminum and aging have been associated with neurobehavioral changes inmammals. This study assessed in young (21 day old), adult (8 months), and old rats (16 months) the effects of prolonged aluminum ingestion on open-field activity and passive-avoidance conditioning. Aluminum was administered in drinking water as aluminum nitrate at doses of 0, 50, and 100 mg Al/kg/day over a 6.5 month period. There were no aluminum effects on the horizontal and vertical activity in an open-field, or in passive-avoidance learning in any group. On the other hand, measurement of aluminum concentrations in a number of brain regions indicated that the olfactory bulb and the rhachidical bulb were the regions with the highest aluminum levels, while the cortex and the thalamus were the cerebral regions showing the lowest aluminum content. For most brain regions analyzed the highest aluminum concentrations were found in young rats, which would indicate that early stages of the life cycle must be considered for enhanced brain aluminum accumulation. [References: 48]
机译：铝和老化都与哺乳动物的神经行为改变有关。这项研究评估了年轻（21天大），成年（8个月）和成年大鼠（16个月）中铝的长期摄入对开放视野活动和被动回避条件的影响。在6.5个月内以0、50和100 mg Al / kg / day的剂量在饮用水中以硝酸铝形式施用铝。在开放视野或任何小组的被动回避学习中，铝对水平和垂直活动没有影响。另一方面，对多个大脑区域的铝浓度进行测量表明，嗅球和横纹球是铝含量最高的区域，而皮质和丘脑是铝含量最低的大脑区域。对于大多数分析的大脑区域，在幼鼠中发现的铝含量最高，这表明必须考虑生命周期的早期阶段才能增强脑铝的积累。 [参考：48]

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