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首页> 外文期刊>Life sciences >CHRONIC DIPYRIDAMOLE ADMINISTRATION DOWNREGULATES [H-3]NITROBENZYLTHIOINOSINE BINDING SITE AFFINITY IN GUINEA PIG KIDNEY BUT NOT HEART AND BRAIN
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CHRONIC DIPYRIDAMOLE ADMINISTRATION DOWNREGULATES [H-3]NITROBENZYLTHIOINOSINE BINDING SITE AFFINITY IN GUINEA PIG KIDNEY BUT NOT HEART AND BRAIN

机译：几内亚猪肾脏的慢性二吡咯胺管理下调[H-3]硝基苯甲硫氨酸结合部位的亲和力

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摘要

Specific binding of the nucleoside transporter probe, [H-3]nitrobenzylthioinosine, ([H-3]NBMPR) was measured in washed guinea pig cardiac, renal and forebrain membranes after 14 days of treatment with dipyridamole (37.5 mg/kg, s.c., b.i.d.) or vehicle. When compared to values in vehicle-treated animals, a 100 percent increase in equilibrium dissociation constant (Kd) was observed in the kidney of dipyridamole-treated animals (0.51 +/- 0.04 to 1.0 +/- 0.06, p < 0.01). The maximal binding capacity (Bmax) was unaltered. No changes were observed in the heart or forebrain. The increase in Kd suggests that chronic dipyridamole treatment decreases the apparent binding affinity of NBMPR for kidney nucleoside transporters. Cardiac and brain nucleoside transporters may be either less susceptible to chronic dipyridamole administration or have a different adaptive mechanism. [References: 30]
机译：用双嘧达莫（37.5 mg / kg，sc，出价）或车辆。与赋形剂处理动物的值相比，在双嘧达莫处理动物的肾脏中观察到平衡解离常数（Kd）增加100％（0.51 +/- 0.04至1.0 +/- 0.06，p <0.01）。最大结合能力（Bmax）未改变。心脏或前脑未见变化。 Kd的增加表明慢性双嘧达莫治疗降低了NBMPR对肾脏核苷转运蛋白的表观结合亲和力。心脏和脑核苷转运蛋白可能不易接受慢性双嘧达莫给药，或具有不同的适应性机制。 [参考：30]

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