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首页> 外文期刊>Life sciences >Neurotensin analog NT77 induces regulated hypothermia in the rat.
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Neurotensin analog NT77 induces regulated hypothermia in the rat.

机译：神经降压素类似物NT77诱导大鼠体内体温过低。

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The potential use of hypothermia as a therapeutic treatment for stroke and other pathological insults has prompted the search for drugs that can lower core temperature. Ideally, a drug is needed that reduces the set-point for control of core temperature (T(c)) and thereby induces a regulated reduction in T(c). To this end, a neurotensin analog (NT77) that crosses the blood brain barrier and induces hypothermia was assessed for its effects on the set-point for temperature regulation in the Sprague-Dawley rat by measuring behavioral and autonomic thermoregulatory responses. Following surgical implanation of radiotransmitters to monitor T(c), rats were placed in a temperature gradient and allowed to select from a range of ambient temperatures (T(a)) while T(c) was monitored by radiotelemetry. There was an abrupt decrease in selected T(a) from 29 to 16 degrees C and a concomitant reduction in T(c) from 37.4 to 34.0 degrees C 1 hr after IP injection of 5.0 mg/kg NT77. Selected T(a) and T(c) then recovered to control levels by 1.5 hr and 4 hr, respectively. Oxygen consumption (M) and heat loss (H) were measured in telemetered rats housed in a direct calorimeter maintained at a T(a) of 23.5 degrees C. Injection of NT77 initially led to a reduction in M, little change in H, and marked decrease in T(c). H initially rose but decreased around the time of the maximal decrease in T(c). Overall, NT77 appears to induce a regulated hypothermic response because the decrease in T(c) was preceded by a reduction in heat production, no change in heat loss, and preference for cold T(a)'s. Inducing a regulated hypothermic response with drugs such as NT77 may be an important therapy for ischemic disease and other insults.
机译：将低温作为中风和其他病理损伤的治疗方法的潜在用途促使人们寻找可以降低核心温度的药物。理想地，需要一种药物，该药物可降低控制核心温度的设定点（T（c）），从而诱导T（c）的降低。为此，通过测量行为和自主温度调节反应，评估了穿越血脑屏障并诱导体温过低的神经降压素类似物（NT77）对Sprague-Dawley大鼠温度调节设定点的影响。在通过外科手术植入无线电发射器以监测T（c）之后，将大鼠置于温度梯度中，并允许其从一系列环境温度（T（a））中进行选择，同时通过无线电遥测法监测T（c）。 IP注射5.0 mg / kg NT77 1小时后，选定的T（a）从29摄氏度突然降低至16摄氏度，T（c）从37.4摄氏度降至34.0摄氏度。然后将选定的T（a）和T（c）分别在1.5小时和4小时内恢复到对照水平。在保持在23.5摄氏度的T（a）的直接热量计中的遥测大鼠中测量耗氧量（M）和热量损失（H）.NT77的注射最初导致M降低，H几乎没有变化和T（c）明显降低。 H最初上升，但在T（c）最大下降的时间前后下降。总的来说，NT77似乎诱导了调节性的低温反应，因为T（c）的降低是热量产生的减少，热量损失没有变化以及对冷T（a）的偏好。用诸如NT77之类的药物诱导调节的低温反应可能是缺血性疾病和其他损伤的重要疗法。

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