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首页> 外文期刊>Life sciences >IFN-gamma production in rabbits: behavioral and endocrine correlates.
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IFN-gamma production in rabbits: behavioral and endocrine correlates.

机译：兔的IFN-γ产生：行为和内分泌相关。

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Freely interacting male rabbits were studied to establish the effect of exogenous testosterone on interferon-gamma (IFN-gamma) production in peripheral blood mononuclear cells (PBMCs) and to evaluate if this effect is related to season, social rank, plasma corticosterone and glucocorticoid receptors (GcR) in PBMCs. Dominance behavior increases after testosterone propionate (TP) administration only in rank 1 animals, while submission behavior increases after TP only in rank 4 animals, indicating a reinforcing effect of TP on the behavior. Corticosterone and IFN-gamma production are higher and GcR binding capacity is lower in spring than in autumn, suggesting that seasonal fluctuations in the immune system may be related to the pattern of secretion of immunomodulatory hormones. In autumn, corticosterone decreases after TP treatment and increases after social interaction, while GcR binding capacity decreases after TP treatment and social interaction. IFN-gamma production decreases in spring and increases in autumn after TP treatment plus social interaction, indicating that the modulating action of testosterone is related to the current immune status. The relationship between dominance, testosterone and the immune system in spring is suggested by the finding that GcR binding capacity after TP treatment is directly related to social rank, as confirmed by the positive correlation with dominance behavior frequency. The dominance index is positively correlated with GcR binding capacity and negatively with IFN-gamma production before TP treatment, indicating that high receptor activity in immunocompetent cells and low immunoreactivity could be prerequisites for dominance behavior. The immunosuppressive effect of corticosterone and the mechanism of down-regulation on GcR are confirmed by the negative correlations with IFN-gamma production and GcR binding capacity.
机译：研究了自由相互作用的雄兔，以建立外源睾酮对外周血单核细胞（PBMC）中干扰素-γ（IFN-γ）产生的影响，并评估这种影响是否与季节，社会地位，血浆皮质酮和糖皮质激素受体有关PBMC中的（GcR）。仅在第1级动物中施用丙酸睾丸激素（TP）后，优势行为增加，而在第4级动物中仅在TP后施用屈服行为增加，这表明TP对行为有增强作用。春季比秋季，皮质酮和IFN-γ的产量更高，GcR的结合能力较低，这表明免疫系统的季节性波动可能与免疫调节激素的分泌方式有关。在秋季，皮质激素在TP治疗后减少，在社交互动后增加，而GcR结合能力在TP治疗和社交互动后降低。 TP治疗加社交互动后，IFN-γ的产生在春季减少，在秋季增加，表明睾丸激素的调节作用与当前的免疫状态有关。 TP处理后的GcR结合能力与社会地位直接相关，这一发现表明了优势，睾丸激素与春季免疫系统之间的关系，这一点与优势行为频率呈正相关。在TP处理之前，优势指数与GcR结合能力呈正相关，与IFN-γ的产生呈负相关，表明免疫感受态细胞中高受体活性和低免疫反应性可能是主导行为的先决条件。皮质酮的免疫抑制作用和对GcR的下调机制已通过与IFN-γ产生和GcR结合能力的负相关而得到证实。

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