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Expression of vascular endothelial growth factor (VEGF) and its cognate receptors in human pheochromocytomas

机译：血管内皮生长因子及其相关受体在人类嗜铬细胞瘤中的表达

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Pheochromocytomas are well-vascularized tumors, suggesting that a potent angiogenic factor may be involved in the mechanism of their formation. As vascular endothelial growth factor (VEGF) is a potent mitogen for vascular endothelial cells, here we have investigated the mRNA and protein expression of VEGF and the mRNA expression of its two receptors (Flt-1 and Flk-1/KDR) in pheochromocytomas tissue. An increase in VEGF mRNA (mainly isoforms VEGF(121) and VEGF(165)) and in VEGF protein expression were observed by semi-quantitative RT-PCR and Western blot, respectively, compared to normal adrenomedullary tissue. Flk-1/KDR, and Flt-1 levels of mRNA were also increased markedly in tumors and correlated with levels of VEGF mRNA. Therefore, we speculate that upregulation of VEGF expression and its receptors might be important in the pathogenesis of pheochromocytomas. (C) 2003 Published by Elsevier Inc. [References: 37]
机译：嗜铬细胞瘤是血管形成良好的肿瘤，提示强力血管生成因子可能参与了其形成机制。由于血管内皮生长因子（VEGF）是血管内皮细胞的有效促分裂原，因此我们研究了嗜铬细胞瘤组织中VEGF的mRNA和蛋白表达以及其两个受体（Flt-1和Flk-1 / KDR）的mRNA表达。 。与正常肾上腺髓质组织相比，分别通过半定量RT-PCR和Western印迹观察到VEGF mRNA（主要是同工型VEGF（121）和VEGF（165））和VEGF蛋白表达的增加。肿瘤中Flk-1 / KDR和Flt-1的mRNA水平也显着升高，并与VEGF mRNA的水平相关。因此，我们推测VEGF表达及其受体的上调在嗜铬细胞瘤的发病机理中可能是重要的。 （C）2003年由Elsevier Inc.发行。[参考：37]

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