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首页> 外文期刊>Life sciences >Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells
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Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells

机译：红曲米提取物通过下调脂肪形成转录因子和3T3-L1细胞中的基因表达来抑制脂肪形成

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The effects of red yeast rice extracts (RE) on adipocyte differentiation of 3T3-L1 cells were studied. RE were extracted from embryonic rice fermented with red yeast (Monascus ruber). These extracts significantly decreased glycerol-3-phosphate dehydrogenase (GPDH) activity and lipid accumulation, a marker of adipogenesis, in a dose-dependent manner. Moreover, mRNA expression levels of both CCAAT/enhancer binding protein (C/EBP) alpha and peroxisome proliferator-activated receptor (PPAR) gamma, the key adipogenic transcription factors, were markedly decreased by RE. RE also inhibited the expression of PPARgamma at protein levels. RE decreased significantly gene expression of adipocyte fatty acid binding protein (aP2) and leptin, which are adipogenic market proteins and C/EBPalpha and PPARgamma target genes. These results suggest that the inhibitory effect of RE on adipocyte differentiation might be mediated through the down-regulated expression of adipogenic transcription factors and other specific genes. (C) 2004 Elsevier Inc. All rights reserved.
机译：研究了红曲米提取物（RE）对3T3-L1细胞脂肪细胞分化的影响。 RE是从用红色酵母（红曲霉）发酵的胚芽米中提取的。这些提取物以剂量依赖的方式显着降低了3-磷酸甘油脱氢酶（GPDH）的活性和脂质积累（脂肪形成的标志物）。此外，RE显着降低了CCAAT /增强子结合蛋白（C / EBP）α和过氧化物酶体增殖物激活受体（PPAR）γ（主要的成脂转录因子）的mRNA表达水平。 RE还可以在蛋白质水平上抑制PPARγ的表达。 RE显着降低了脂肪细胞脂肪酸结合蛋白（aP2）和瘦素的基因表达，这是脂肪形成的市场蛋白以及C / EBPalpha和PPARgamma目标基因。这些结果表明，RE对脂肪细胞分化的抑制作用可能是通过下调脂肪形成转录因子和其他特定基因的表达来介导的。 （C）2004 Elsevier Inc.保留所有权利。

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