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首页> 外文期刊>Life sciences >MATURE HUMAN ATHEROSCLEROTIC PLAQUE CONTAINS PEROXIDIZED PHOSPHATIDYLCHOLINE AS A MAJOR LIPID PEROXIDE
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MATURE HUMAN ATHEROSCLEROTIC PLAQUE CONTAINS PEROXIDIZED PHOSPHATIDYLCHOLINE AS A MAJOR LIPID PEROXIDE

机译：成熟的人动脉粥样硬化斑块含有过氧化的磷脂酰胆碱作为主要的脂质过氧化物

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The initial stage of atherosclerotic plaque formation involves oxidation of the phosphatidyl-choline moiety of low density lipoprotein (LDL) and subsequent uptake by macrophages. Ongoing uptake in developing plaque also may involve oxidized LDL and would require an oxidizing environment in plaque lipids. Atherosclerotic plaque lipids from 12 patients undergoing peripheral vascular procedures were extracted in chloroform: methanol This extract was applied to a 25 cm 5 micron silica HPLC column and eluted with a ternary gradient mobile phase utilizing a laser light scattering (ELSD) mass detector. individual lipid fractions were then analyzed. Cholesterol, both free and esterified, was the most prominent lipid in plaque (104 +/- 74 mg/gm tissue) However, lipid peroxides were present in much higher concentration (3.52 +/- 2.84 FU x 10(4)/mg phospholipid) and overall level (21.27 +/- 10.10 FU x 10(4)/gm plaque) in the phospholipid component (*p < 0.05) Phosphatidyl-choline (PC) accounted for 63% of the total phospholipid peroxides recovered (6.31 +/- 5.09 mg/gm plaque; *p < 0.05) PC and phosphatidylinositol (PI) content were linearly related to lipid peroxide fluorescence (PC; r = 0.696; p = 0.01) (PI; r = 0.809; p = 0.001). Lipid peroxides in human atherosclerotic plaque are present primarily in the phospholipid component and phosphatidyl-choline forms the bulk of these peroxides. PC may play an important role in ongoing plaque lipid accumulation. [References: 21]
机译：动脉粥样硬化斑块形成的初始阶段涉及低密度脂蛋白（LDL）的磷脂酰胆碱部分的氧化和随后被巨噬细胞摄取。持续发展中的斑块摄取也可能涉及氧化的LDL，并且需要斑块脂质中存在氧化环境。在氯仿：甲醇中提取12名接受外周血管手术的患者的动脉粥样硬化斑块脂质。将该提取物应用于25 cm 5微米硅胶HPLC色谱柱，并利用激光散射（ELSD）质量检测器用三元梯度流动相洗脱。然后分析各个脂质部分。胆固醇（游离和酯化）是菌斑中最突出的脂质（104 +/- 74 mg / gm组织）。但是，脂质过氧化物的浓度要高得多（3.52 +/- 2.84 FU x 10（4）/ mg磷脂） ）和总水平（21.27 +/- 10.10 FU x 10（4）/ gm噬菌斑）（* p <0.05）磷脂酰胆碱（PC）占回收的磷脂过氧化物总量的63％（6.31 + / -5.09 mg / gm噬菌斑; * p <0.05）PC和磷脂酰肌醇（PI）含量与脂质过氧化物荧光（PC; r = 0.696; p = 0.01）线性相关（PI; r = 0.809; p = 0.001）。人动脉粥样硬化斑块中的脂质过氧化物主要存在于磷脂成分中，而磷脂酰胆碱占这些过氧化物的大部分。 PC可能在正在进行的斑块脂质积累中起重要作用。 [参考：21]

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