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首页> 外文期刊>Life sciences >DECREASED TUMOR INCIDENCE AND INCREASED SURVIVAL BY ONE YEAR ORAL LOW DOSE ARGININE SUPPLEMENTATION IN THE MOUSE
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DECREASED TUMOR INCIDENCE AND INCREASED SURVIVAL BY ONE YEAR ORAL LOW DOSE ARGININE SUPPLEMENTATION IN THE MOUSE

机译：小鼠中口服低剂量精氨酸补充一年的肿瘤发病率和存活率下降

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The effects of arginine on tumor growth, antitumor mechanisms and a potential therapeutic role have been reviewed recently. In these studies, however controversial they were, high dose protocols for arginine treatment have been applied. Based upon own recent findings that low dose arginine stimulates the immune system and blocks lipid peroxidation, we performed preventive treatment with low dose (50 mg/kg body weight per day, orally administered) L-arginine in 150 mice for a period of one year. We compared survival and total number of tumors at the end of the feeding period to that found in 150 mice given taurine in the same dosage and in 150 mice without treatment. Survival of the arginine treated group was statistically significant as compared to that of the control group without treatment (p<0.05): 116 mice were alive in the control group, 122 in the group administered taurine and 132 in the arginine treated group. The total number of tumors was significantly lower in the arginine treated group vs. the control group (p<0.01). The total number of malign and benign tumors was significantly lower in the arginine treated group, whereas taurine significantly reduced the number of benign tumors only (p<0.05). Arginine and taurine stimulate the immune system at the lymphocyte level. Arginine also acts at the macrophage level, inducing nitric oxide mediated cytotoxicity against tumor cells. Both compounds are known to block the formation of lipid peroxidation products. We therefore suggest that these two mechanisms are responsible for the decreased total number of tumors and the concomitant increase in survival. [References: 34]
机译：最近综述了精氨酸对肿瘤生长，抗肿瘤机制和潜在治疗作用的影响。在这些研究中，尽管有争议，但已应用高剂量精氨酸治疗方案。根据自己最近的发现，即低剂量精氨酸刺激免疫系统并阻止脂质过氧化，我们对150只小鼠的低剂量（每天口服50 mg / kg体重）L-精氨酸进行了预防性治疗，为期一年。我们将喂养期末的存活率和肿瘤总数与以相同剂量服用牛磺酸的150只小鼠和未经治疗的150只小鼠的存活率和肿瘤总数进行了比较。与未治疗的对照组相比，精氨酸治疗组的存活率具有统计学意义（p <0.05）：对照组中存活的小鼠为116只，牛磺酸组的存活率为122只，精氨酸治疗组的存活率为132只。精氨酸治疗组的肿瘤总数明显低于对照组（p <0.01）。在精氨酸治疗组中，恶性肿瘤和良性肿瘤的总数明显减少，而牛磺酸仅显着减少了良性肿瘤的数目（p <0.05）。精氨酸和牛磺酸在淋巴细胞水平上刺激免疫系统。精氨酸还作用于巨噬细胞水平，诱导一氧化氮介导的针对肿瘤细胞的细胞毒性。已知这两种化合物都能阻止脂质过氧化产物的形成。因此，我们建议这两种机制是导致肿瘤总数减少和存活率增加的原因。 [参考：34]

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