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首页> 外文期刊>Life sciences >INDUCTION OF IMMEDIATE-EARLY, ORNITHINE DECARBOXYLASE AND ANTIZYME GENE EXPRESSION IN THE RAT SMALL INTESTINE AFTER TRANSIENT ISCHAEMIC
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INDUCTION OF IMMEDIATE-EARLY, ORNITHINE DECARBOXYLASE AND ANTIZYME GENE EXPRESSION IN THE RAT SMALL INTESTINE AFTER TRANSIENT ISCHAEMIC

机译：短暂性脑缺血后大鼠小肠中正丁氨酸脱羧酶和抗酶基因表达的诱导

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摘要

The expression of the immediate early genes (IEG)s c-fos, c-jun and zif/268, and the genes coding for ornithine decarboxylase (ODC) and its regulatory protein antizyme (AZ), was studied in rat small intestine following transient ischemia. The ischemic stimulus for 10 min alone did not alter the expression of these genes. A rapid and transitory induction of all IEG mRNAs occurred in a coordinated manner peaking at 30 min following recirculation and returned to basal levels 3 hr after recirculation. Protein products of the IEGs accumulated in the smooth muscle layer of the intestine by 2-3 hr after recirculation. Expression of both ODC and AZ, mRNAs initially decreased to 70% of control levels 1 hr after recirculation but markedly increased at 2 to 4 hr after recirculation. The functional significance of these changes in gene expression in relation to tissue integrity and function after the ischaemia/reperfusion is discussed. [References: 29]
机译：研究了瞬态后大鼠小肠中立即早期基因（IEG）c-fos，c-jun和zif / 268的表达以及鸟氨酸脱羧酶（ODC）及其调节蛋白抗酶（AZ）的编码基因。缺血。仅10分钟的局部缺血刺激就不会改变这些基因的表达。对所有IEG mRNA的快速而短暂的诱导以协调的方式发生，在再循环后30分钟达到峰值，并在再循环3小时后恢复至基础水平。再循环后2-3小时，IEG的蛋白质产物积聚在肠的平滑肌层中。循环后1小时，ODC和AZ，mRNA的表达最初均降至对照水平的70％，但在循环后2至4小时则显着增加。讨论了缺血/再灌注后这些基因表达变化与组织完整性和功能有关的功能意义。 [参考：29]

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