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首页> 外文期刊>Life sciences >Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS).
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Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS).

机译：强电子电荷是壳寡糖（COS）抗癌活性的重要因素。

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Even though several studies report the importance of chitosan derivatives for their anticancer activity, no clear information is available to describe the relationship between their charge properties and observed activities. In this research, differently charged chitooligosaccharide (COS) derivatives were synthesized and their anticancer activities were studied using three cancer cell lines, HeLa, Hep3B and SW480. Neutral red and MTT cell viability studies revealed that, highly charged COS derivatives could significantly reduce cancer cell viability, regardless to the positive or negative charge. Further, fluorescence microscopic observations and DNA fragmentation studies confirmed that the anticancer effect of these highly charged COS derivatives were due to necrosis. However, the exact molecular mechanism for anticancer activity of strongly charged COS compared to their poorly charged counterparts is not clear.
机译：尽管几项研究报告了壳聚糖衍生物对其抗癌活性的重要性，但尚无明确信息可描述壳聚糖衍生物的电荷性质与观察到的活性之间的关系。在这项研究中，合成了带不同电荷的壳寡糖（COS）衍生物，并使用三种癌细胞系HeLa，Hep3B和SW480研究了它们的抗癌活性。中性红和MTT细胞活力研究表明，带高电荷的COS衍生物可显着降低癌细胞的活力，无论带正电荷还是带负电荷。此外，荧光显微镜观察和DNA片段研究证实，这些高电荷COS衍生物的抗癌作用是由于坏死引起的。但是，与带电较弱的对应物相比，带电较弱的COS抗癌活性的确切分子机制尚不清楚。

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