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首页> 外文期刊>Life sciences >Apparent diffusion coefficient in the aging mouse brain: a magnetic resonance imaging study.
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Apparent diffusion coefficient in the aging mouse brain: a magnetic resonance imaging study.

机译：衰老小鼠大脑中的表观扩散系数：磁共振成像研究。

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Novel magnetic resonance imaging sequences have and still continue to play an increasing role in neuroimaging and neuroscience. Among these techniques, diffusion-weighted imaging (DWI) has revolutionized the diagnosis and management of diseases such as stroke, neoplastic disease and inflammation. However, the effects of aging on diffusion are yet to be determined. To establish reference values for future experimental mouse studies we tested the hypothesis that absolute apparent diffusion coefficients (ADC) of the normal brain change with age. A total of 41 healthy mice were examined by T2-weighted imaging and DWI. For each animal ADC frequency histograms (i) of the whole brain were calculated on a voxel-by-voxel basis and region-of-interest (ROI) measurements (ii) performed and related to the animals' age. The mean entire brain ADC of mice <3 months was 0.715(+/-0.016) x 10(-3) mm2/s, no significant difference to mice aged 4 to 5 months (0.736(+/-0.040) x 10(-3) mm2/s) or animals older than 9 months 0.736(+/-0.020) x 10(-3) mm2/s. Mean whole brain ADCs showed a trend towards lower values with aging but both methods (i + ii) did not reveal a significant correlation with age. ROI measurements in predefined areas: 0.723(+/-0.057) x 10(-3) mm2/s in the parietal lobe, 0.659(+/-0.037) x 10(-3) mm2/s in the striatum and 0.679(+/-0.056) x 10(-3) mm2/s in the temporal lobe. With advancing age, we observed minimal diffusion changes in the whole mouse brain as well as in three ROIs by determination of ADCs. According to our data ADCs remain nearly constant during the aging process of the brain with a small but statistically non-significant trend towards a decreased diffusion in older animals.
机译：新的磁共振成像序列已经并且继续在神经成像和神经科学中发挥越来越重要的作用。在这些技术中，扩散加权成像（DWI）彻底改变了中风，肿瘤性疾病和炎症等疾病的诊断和管理。但是，老化对扩散的影响尚待确定。为了为以后的实验小鼠研究建立参考值，我们测试了正常大脑的绝对表观扩散系数（ADC）随年龄变化的假设。通过T2加权成像和DWI检查总共41只健康小鼠。对于每只动物，ADC的整个大脑的频率直方图（i）均以逐像素进行计算，并进行感兴趣区域（ROI）测量（ii）并与动物年龄有关。小于3个月的小鼠的平均全脑ADC为0.715（+/- 0.016）x 10（-3）mm2 / s，与4到5个月大的小鼠（0.736（+/- 0.040）x 10（- 3）mm2 / s）或大于9个月的动物0.736（+/- 0.020）x 10（-3）mm2 / s。平均全脑ADC显示随着年龄的增长而趋向于较低值的趋势，但两种方法（i + ii）均未显示出与年龄的显着相关性。在预定区域中的ROI测量：顶叶为0.723（+/- 0.057）x 10（-3）mm2 / s，纹状体为0.659（+/- 0.037）x 10（-3）mm2 / s和0.679（+ /-0.056）x 10（-3）mm2 / s在颞叶。随着年龄的增长，我们通过测定ADC观察到整个小鼠大脑以及三个ROI中的扩散变化最小。根据我们的数据，ADC在大脑衰老过程中几乎保持恒定，但在老年动物中扩散减少的趋势很小，但在统计上却不显着。

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