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Perinatal salt restriction: A new pathway to programming adiposity indices in adult female Wistar rats

机译：围产期盐限制：成年雌性Wistar大鼠编程肥胖指数的新途径

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摘要

Low birth weight has been associated with increased obesity in adulthood. It has been shown that dietary salt restriction during intrauterine life induces low birth weight and insulin resistance in adult Wistar rats. The present study had a two-fold objective: to evaluate the effects that low salt intake during pregnancy and lactation has on the amount and distribution of adipose tissue; and to determine whether the phenotypic changes in fat mass in this model are associated with alterations in the activity of the renin-angiotensin system. Maternal salt restriction was found to reduce birth weight in male and female offspring. In adulthood, the female offspring of dams fed the low-salt diet presented higher adiposity indices than those seen in the offspring of dams fed a normal-salt diet. This was attributed to the fact that adipose tissue mass (retroperitoneal but not gonadal, mesenteric or inguinal) was greater in those rats than in the offspring of dams fed a normal diet. The adult offspring of dams fed the low-salt diet, compared to those dams fed a normal-salt diet, presented the following: plasma leptin levels higher in males and lower in females; plasma renin activity higher in males but not in females; and no differences in body weight, mean arterial blood pressure or serum angiotensin-converting enzyme activity. Therefore, low salt intake during pregnancy might lead to the programming of obesity in adult female offspring. (c) 2009 Elsevier Inc. All rights reserved.
机译：低出生体重与成人肥胖增加有关。业已表明，宫内节育期饮食中的盐分限制会导致成年Wistar大鼠的出生体重下降和胰岛素抵抗。本研究有两个目的：评估怀孕和哺乳期间低盐摄入量对脂肪组织的数量和分布的影响。并确定该模型中脂肪量的表型变化是否与肾素-血管紧张素系统活性的改变有关。发现限制母体盐可以降低雄性和雌性后代的出生体重。在成年期，饲喂低盐饮食的大坝雌性后代的肥胖指数高于饲喂普通盐饮食的大坝后代。这归因于以下事实：在这些大鼠中，脂肪组织质量（腹膜后腹膜，但不是性腺，肠系膜或腹股沟）要比饲喂正常饮食的水坝后代更大。与低盐饮食相比，低盐饮食的大坝成年后代具有以下特征：男性的血浆瘦素水平较高，女性的血浆瘦素水平较低。男性的血浆肾素活性较高，但女性则不高;体重，平均动脉血压或血清血管紧张素转化酶活性无差异。因此，怀孕期间低盐摄入可能导致成年雌性后代肥胖。 （c）2009 Elsevier Inc.保留所有权利。

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