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首页> 外文期刊>Life sciences >Neuroprotection achieved in the ischaemic rat cortex with L-kynurenine sulphate
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Neuroprotection achieved in the ischaemic rat cortex with L-kynurenine sulphate

机译：L-犬尿氨酸硫酸盐在缺血大鼠皮质中的神经保护作用

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L-Kynurenine is a metabolic precursor of kynurenic acid, which is one of the few known endogenous N-methyl-D-aspartate receptor inhibitors. In contrast with kynurenic acid, L-kynurenine is transported across the blood-brain barrier, and it may therefore come into consideration as a therapeutic agent in certain neurobiological disorders, e.g. ischaemia-induced events. The present study evaluated the effect Of L-kynurenine administration (300 mg/kg i.p.) on the global ischaemic brain cortex both pre- and post-ischemic intervention. The statistical evaluation revealed that L-kynurenine administration beneficially decreased the number of neurones injured per mm(2) in the cortex, not only in the pre-treated animals, but also in those which received L-kynurenine after the ischaemic insult. It is concluded that even the post-traumatic administration of L-kynurenine may be of substantial therapeutic benefit in the treatment of global brain ischaemia. This is the first histological proof of the neuroprotective effect achieved by the post-traumatic administration Of L-kynurenine in the global ischaemic cortex. (c) 2008 Elsevier Inc. All rights reserved.
机译：L-Kynurenine是Kynurenic酸的代谢前体，它是为数不多的已知内源性N-甲基-D-天冬氨酸受体抑制剂之一。与犬尿酸相反，L-犬尿氨酸跨血脑屏障转运，因此可以考虑作为某些神经生物学疾病（例如糖尿病）的治疗剂。缺血引起的事件。本研究评估了L-犬尿氨酸（300 mg / kg i.p.）给药对缺血前和干预后整体缺血性大脑皮层的影响。统计评估表明，不仅在预处理动物中，而且在缺血性损伤后接受L-犬尿氨酸的动物中，L-犬尿氨酸的施用均有益地减少了每mm（2）皮层中受伤的神经元数量。结论是，即使在创伤后施用L-犬尿氨酸也可能在整体脑缺血的治疗中具有实质性的治疗益处。这是创伤后给予L-犬尿氨酸在整体缺血皮层中实现的神经保护作用的第一个组织学证据。 （c）2008 Elsevier Inc.保留所有权利。

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