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首页> 外文期刊>Life sciences >Differential feeding responses to central alpha-melanocyte stimulating hormone in genetically low and high body weight selected lines of chickens.
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Differential feeding responses to central alpha-melanocyte stimulating hormone in genetically low and high body weight selected lines of chickens.

机译：在遗传上体重低和体重高的鸡品系中，对中央α-黑素细胞刺激激素的不同饲喂反应。

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This study was conducted to compare the effects of central alpha-MSH, a potent anorexigenic signal, in lines of chickens that have undergone long-term divergent selection for low (LWS) or high (HWS) body weight. Chicks from both lines were centrally injected with 0, 24, 120 or 600 pmol alpha-MSH and feed and water intake were concurrently measured thereafter for a total of 180 min. The LWS line responded to all doses of alpha-MSH with a similar potent decrease in feed intake at all observation times. The HWS line only responded to 600 pmol alpha-MSH with decreased feed intake. alpha-MSH did not influence water intake in either line. To determine if differential hypothalamic signaling was associated with the anorexigenic effect, c-Fos immunoreactivity was measured in appetite-related hypothalamic nuclei after 600 pmol central alpha-MSH injections. c-Fos immunoreactivity was increased in the dorsomedial hypothalamus, paraventricular nucleus (PVN) and ventromedial hypothalamus in both lines after alpha-MSH; however, the magnitude of increase was greater in LWS than in HWS chicks at the PVN (136% vs. 47% increase over controls, respectively). Based on behavior observations, the number of feeding and exploratory pecks is decreased with greater magnitude after alpha-MSH in the LWS line. Additionally, alpha-MSH was associated with increased deep rest in both lines, and may be a secondary effect to reduced ingestion. These data support that the LWS line has a lower threshold for the anorexigenic effect of central alpha-MSH while in the HWS line this threshold is higher, and that this difference may be associated with differential hypothalamic signaling. Genetic variation exists in the threshold of anorexigenic response for central alpha-MSH in LWS and HWS lines of chickens with possible implications to other species including humans.
机译：进行这项研究的目的是比较中长期α-MSH（一种强效的厌食信号）对低体重（LWS）或高体重（HWS）的长期不同选择的鸡株的影响。将来自两个生产线的小鸡集中注射0、24、120或600 pmolα-MSH，然后同时测量饲料和摄水量，总计180分钟。 LWS品系对所有α-MSH剂量都有反应，在所有观察时间中采食量都有类似的有效下降。 HWS生产线仅对600 pmol alpha-MSH做出反应，饲料采食量减少。 alpha-MSH不会影响任何一条管线的进水量。为了确定差异性下丘脑信号传导是否与厌食作用有关，在600 pmol中央α-MSH注射后，在食欲相关的下丘脑核中测量了c-Fos免疫反应性。 α-MSH后两系的背侧下丘脑，室旁核（PVN）和腹侧下丘脑的c-Fos免疫反应性均增加;然而，在PVN处，LWS的增加幅度大于HWS雏鸡（分别比对照增加136％和47％）。根据行为观察，在LWS系中进行alpha-MSH后，进食和探索性啄的数量以更大的幅度减少。此外，α-MSH与两条线的深度休息增加有关，可能是减少摄入的次要作用。这些数据支持LWS线对中枢α-MSH的厌食作用具有较低的阈值，而在HWS线中，该阈值较高，并且该差异可能与下丘脑差异信号有关。在鸡的LWS和HWS系中，中央α-MSH的厌食反应阈值中存在遗传变异，可能对包括人类在内的其他物种产生影响。

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