• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Inhibition of monoamine oxidase isoforms modulates nicotine withdrawal syndrome in the rat
【24h】

Inhibition of monoamine oxidase isoforms modulates nicotine withdrawal syndrome in the rat

机译：单胺氧化酶同工型的抑制调节大鼠尼古丁戒断综合征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aims There have been many reports of monoamine oxidase (MAO) inhibition by non-nicotine ingredients in tobacco smoke, persisting for days after smoking cessation. This study determined the effect of inhibiting MAO and its isoforms on nicotine withdrawal syndrome. Main methods Rats were rendered nicotine-dependent by seven days of subcutaneous (s.c.) 9 mg/kg/day infusion of nicotine bitartrate. Twenty-two hours after termination of infusion, they were observed over 20 min for somatically expressed nicotine withdrawal signs. Three hours before observation, rats were injected intraperitoneally (i.p.) with 4 mg/kg each of the MAO A antagonist clorgyline and the MAO B antagonist deprenyl, or with saline alone. A similar experiment was performed with non-dependent, saline-infused rats. Another experiment compared nicotine-dependent rats that received injections of either saline or 4 mg/kg clorgyline alone. A further experiment compared rats receiving either saline or 4 mg/kg deprenyl alone. Key findings Combined treatment with both MAO inhibitors markedly and significantly exacerbated somatically expressed nicotine withdrawal signs in nicotine infused rats, while having no significant effects in saline-infused rats. Rats injected s.c. with 4 mg/kg clorgyline alone had significantly more withdrawal signs than saline-injected rats, while deprenyl-injected rats had significantly fewer signs than saline controls. Assays confirmed that clorgyline thoroughly reduced MAO A enzymatic activity and deprenyl thoroughly reduced MAO B activity. Significance The results suggest that inhibition of MAO A may contribute to the intensity of withdrawal syndrome in smoking cessation.
机译：目的已有许多关于烟中非烟碱成分对单胺氧化酶（MAO）的抑制作用的报道，这种现象在戒烟后持续数天。这项研究确定了抑制MAO及其同工型对尼古丁戒断综合征的作用。主要方法通过皮下注射（s.c.）7毫克/千克/天的酒石酸尼古丁7天，使大鼠依赖尼古丁。输注终止后二十二小时，在20分钟内观察到它们的体细胞表达尼古丁戒断症状。观察前三小时，给大鼠腹膜内（i.p.）分别注射4 mg / kg的MAO A拮抗剂克来啉和MAO B拮抗剂去异戊二烯，或仅注射盐水。对非依赖性，注入盐水的大鼠进行了类似的实验。另一个实验比较了单独注射生理盐水或4 mg / kg盐酸高粱碱的尼古丁依赖性大鼠。进一步的实验比较了仅接受盐水或4 mg / kg异戊二烯基的大鼠。关键发现在注射尼古丁的大鼠中，两种MAO抑制剂的联合治疗显着并显着加剧了躯体表达的尼古丁戒断症状，​​而在注射生理盐水的大鼠中无明显作用。皮下注射大鼠单独使用浓度为4 mg / kg的盐酸高粱碱的大鼠的戒断症状要明显多于注射生理盐水的大鼠，而注射异戊二烯基的大鼠的戒断症状明显少于生理盐水对照组。分析证实，高粱茶碱彻底降低了MAO A的酶活性，而异戊二烯基彻底降低了MAO B的活性。有意义的结果表明，抑制MAO A可能有助于戒烟中戒断综合征的强度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号