• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Effect of adenovirus and influenza virus infection on obesity
【24h】

Effect of adenovirus and influenza virus infection on obesity

机译：腺病毒和流感病毒感染对肥胖的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of this review is to provide an overview of the effects of adenovirus and influenza virus infections on obesity in various experimental models. We reviewed studies that were conducted within the past 10 years and were related to virus infection and obesity prevalence. Here, we discuss a different causal relationship between adenovirus and influenza infections with obesity. Adenovirus infection can cause obesity, whereas obesity can be a risk factor for increasing influenza virus infection and increases the risk of morbidity and mortality. The prevalence of obesity due to adenovirus infections may be due to an increase in glucose uptake and reduction in lipolysis caused by an increase in corticosterone secretion. Adenovirus infections may lead to increases in appetite by decreasing norepinephrine and leptin levels and also cause immune dysfunction. The relationship between obesity and influenza virus infection could be summarized by the following features: decreases in memory T-cell functionality and interferon (IFN)-α, IFN-β, and IFN-γ mRNA expression, increases in viral titer and infiltration, and impaired dendritic cell function in obese individuals. Moreover, leptin resistance may play an important role in increasing influenza virus infections in obese individuals. In conclusion, prevention of adenovirus infections could be a good approach for reducing obesity prevalence, and prevention of obesity could reduce influenza virus infections from the point of view of viral infections and obesity.
机译：这篇综述的目的是概述各种实验模型中腺病毒和流感病毒感染对肥胖的影响。我们回顾了过去10年中进行的与病毒感染和肥胖症患病率有关的研究。在这里，我们讨论了腺病毒和肥胖引起的流感感染之间不同的因果关系。腺病毒感染可引起肥胖，而肥胖可能是增加流感病毒感染的危险因素，并增加发病和死亡的风险。腺病毒感染引起的肥胖症患病率可能是由于糖皮质激素分泌增加引起的葡萄糖摄取增加和脂解减少。腺病毒感染可通过降低去甲肾上腺素和瘦素水平导致食欲增加，并引起免疫功能障碍。肥胖与流感病毒感染之间的关系可以归纳为以下特征：记忆性T细胞功能和干扰素（IFN）-α，IFN-β和IFN-γmRNA表达下降，病毒滴度和浸润增加以及肥胖个体树突细胞功能受损。此外，瘦素抵抗可能在肥胖个体中增加流感病毒感染中起重要作用。总之，从病毒感染和肥胖的角度来看，预防腺病毒感染可能是降低肥胖发生率的好方法，而预防肥胖可以减少流感病毒感染。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号