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首页> 外文期刊>Life sciences >Progesterone restores the female prostate activity in ovariectomized gerbil and may act as competitor of testosterone in intraprostatic environment
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Progesterone restores the female prostate activity in ovariectomized gerbil and may act as competitor of testosterone in intraprostatic environment

机译：孕酮可恢复去卵巢沙鼠中的女性前列腺活性，并可能在前列腺内环境中充当睾丸激素的竞争者

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Aims Little is known about the effect of progesterone on gerbil female prostate. It is known that normal oscillation in the progesterone and estradiol levels during the estrous cycle phases influence the morphophysiology of this gland. The present study aims to evaluate the isolated effect of prolonged administration of progesterone combined or not with testosterone on the prostate of ovariectomized female gerbil. Main methods To observe the morphological changes caused by castration in the prostate of different groups stereologic analyses of all prostate compartments, analysis of nuclear area and perimeter, and morphometric measurements of epithelial and smooth muscle cells layers were used. In addition, immunocytochemistry was performed to investigate the distribution of the androgen, estrogen alfa and beta and progesterone receptors in different prostatic compartments. Key findings This study demonstrated that both treatments partially recovered the structure of the gland. In the group treated with progesterone plus testosterone a higher incidence of epithelial and stromal disorders occurred, besides the absence of secretory activity. Thus, treatment only with progesterone showed better results in the restoration of glandular homeostasis mainly seen by the regulation of the secretory activity. Significance Collectively, the findings of this study indicate that progesterone may have a significant role on the maintenance of prostate morphophysiology, and showed an interesting evidence of hormonal competition between progesterone and testosterone.
机译：目的关于孕酮对沙鼠雌性前列腺的影响知之甚少。众所周知，在发情周期阶段，孕酮和雌二醇水平的正常振荡会影响该腺体的形态生理。本研究旨在评估长期联合使用或不联合使用睾丸激素与睾丸激素对卵巢切除雌性沙鼠的前列腺的孤立作用。主要方法为了观察不同组前列腺去势引起的形态变化，对所有前列腺区室进行了立体分析，核面积和周长分析以及上皮和平滑肌细胞层的形态测量。另外，进行了免疫细胞化学研究在不同的前列腺区室中雄激素，雌激素α和β和孕激素受体的分布。关键发现这项研究表明，两种治疗均能部分恢复腺体的结构。在孕激素加睾丸激素治疗组中，除了缺乏分泌活性外，上皮和间质疾病的发生率更高。因此，仅通过黄体酮治疗在腺稳态的恢复中显示出更好的结果，这主要是通过调节分泌活性看到的。有意义的是，这项研究的结果表明，孕酮可能对维持前列腺形态生理有重要作用，并显示出有趣的证据表明孕酮和睾丸激素之间存在激素竞争。

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