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首页> 外文期刊>Life sciences >Preventive and therapeutic anti-TNF-α therapy with pentoxifylline decreases arthritis and the associated periodontal co-morbidity in mice
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Preventive and therapeutic anti-TNF-α therapy with pentoxifylline decreases arthritis and the associated periodontal co-morbidity in mice

机译：己酮可可碱的预防性和治疗性抗TNF-α治疗可减少小鼠的关节炎和相关的牙周合并症

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Aims The association between rheumatoid arthritis (RA) and periodontal disease (PD) has long been studied and some reports suggest that treating RA may improve the associated PD, and vice versa. This study aimed to evaluate the effects of an anti-tumor necrosis factor (TNF)-α therapy with pentoxifylline (PTX) in an experimental model of RA-associated PD. Main methods Male C57BL/6 mice were subjected to chronic antigen-induced arthritis (AIA) and daily treated with PTX (50 mg/kg, i.p.) using preventive (Pre-PTX) or therapeutic (The-PTX) strategies. Fourteen days after the antigen challenge, mice were euthanized and knee joints, maxillae and serum were collected for microscopic and/or immunoenzymatic analysis. Key findings AIA triggered significant leukocyte recruitment to the synovial cavity, tissue damage and proteoglycan loss in the knee joint. Pre-PTX and The-PTX regimens decreased these signs of joint inflammation. The increased levels of TNF-α and IL-17 in periarticular tissues of AIA mice were also reduced by both PTX treatments. Serum levels of C-reactive protein, which were augmented after AIA, were reduced by the PTX regimens. Concomitantly to AIA, mice presented alveolar bone loss, and recruitment of osteoclasts and neutrophils to periodontal tissues. Pre-PTX and The-PTX prevented and treated these signs of PD. PTX treatment also decreased TNF-α and increased IL-10 expression in the maxillae of AIA mice, although it did not affect the expression of IFN-γ and IL-17. Significance The current study shows the anti-inflammatory and bone protective effects of preventive and therapeutic PTX treatments, which decreased the joint damage triggered by AIA and the associated periodontal co-morbidity.
机译：目的长期以来，类风湿性关节炎（RA）与牙周疾病（PD）之间的关联已有研究，并且一些报告表明，治疗RA可以改善相关的PD，反之亦然。这项研究旨在评估己酮可可碱（PTX）的抗肿瘤坏死因子（TNF）-α治疗在与RA相关的PD实验模型中的作用。主要方法对雄性C57BL / 6小鼠进行慢性抗原诱发的关节炎（AIA），每天采用预防性（Pre-PTX）或治疗性（The-PTX）策略进行PTX（50 mg / kg，i.p.）治疗。抗原攻击后第14天，对小鼠实施安乐死，并收集膝关节，上颌骨和血清进行显微镜和/或免疫酶分析。关键发现AIA触发了明显的白细胞募集到滑膜腔，组织损伤和膝关节蛋白聚糖的丢失。 Pre-PTX和The-PTX方案可减轻这些关节发炎的迹象。两种PTX处理均能降低AIA小鼠关节周围组织中TNF-α和IL-17的升高水平。 PTX方案可降低AIA后血清C反应蛋白水平的升高。伴随友邦保险，小鼠出现牙槽骨丢失，破骨细胞和中性粒细胞募集到牙周组织。 Pre-PTX和The-PTX可以预防和治疗PD的这些症状。尽管PTX处理不影响IFN-γ和IL-17的表达，但它也能降低AIA小鼠上颌的TNF-α并增加IL-10的表达。重要性目前的研究表明，预防性和治疗性PTX治疗具有抗炎和骨骼保护作用，可减少AIA引发的关节损伤和相关的牙周合并症。

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