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首页> 外文期刊>Life sciences >EXTRACELLULAR AND INTRACELLULAR EFFECTS OF POLYAMINES ON SMOOTH MUSCLE CONTRACTIONS
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EXTRACELLULAR AND INTRACELLULAR EFFECTS OF POLYAMINES ON SMOOTH MUSCLE CONTRACTIONS

机译：聚酰胺对平滑肌收缩的胞外和胞内作用

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The natural polyamines spermine, spermidine and putrescine, and their metabolic products N-1-acetylspermine (N-AS) and 5'-deoxi-5'-methylthioadenosine (DMT), but not N-1-acetylspermidine nor N-acetylputrescine, relax the KCl-induced contraction in rat uterus in a dose-dependent way. This relaxing effect is counteracted by CaCl2 (0.1-6 mM) but not by Bay K 8644. Spermine, N-AS and DMT also inhibit the contraction induced by methacholine and PGF(2 alpha). Spermine, DMT and N-AS relax the vanadate-induced contraction in uterus incubated in calcium-free solution plus EDTA. However, in the vanadate contraction, the EC(50)s are higher than those obtained with other contracturants. These results suggest that polyamines inhibit smooth muscle contraction by action at plasma membrane level decreasing the influx of calcium. However, intracellular actions of polyamines could also be involved in their effects. [References: 26]
机译：天然的多胺精胺，亚精胺和腐胺及其代谢产物N-1-乙酰精胺（N-AS）和5'-deoxi-5'-甲基硫代腺苷（DMT），而不是N-1-乙酰精胺或N-乙酰基鸟氨酸KCl诱导的大鼠子宫收缩呈剂量依赖性。这种松弛作用被CaCl2（0.1-6 mM）抵消，但不受Bay K 8644抵消。精胺，N-AS和DMT也抑制了乙酰甲胆碱和PGF（2 alpha）诱导的收缩。在无钙溶液和EDTA中孵育的精子，DMT和N-AS可以缓解钒酸盐诱导的子宫收缩。但是，在钒酸盐收缩中，EC（50）比其他收缩剂的EC（50）高。这些结果表明，多胺通过在质膜水平上的作用抑制了钙的流入，从而抑制了平滑肌的收缩。但是，多胺的细胞内作用也可能与它们的作用有关。 [参考：26]

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