• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >GLIPIZIDE STIMULATES SYMPATHETIC OUTFLOW IN DIABETES-PRONE MICE
【24h】

GLIPIZIDE STIMULATES SYMPATHETIC OUTFLOW IN DIABETES-PRONE MICE

机译：格列吡嗪可刺激糖尿病小鼠的交感神经外流

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of the present study was to determine if the oral hypoglycemic agent glipizide influenced sympathetic outflow in diabetes-prone mice. C57BL/6 (diabetes-prone) and diabetes-resistant (A/J) were treated with saline or glipizide, and sympathetic outflow determined by the fall in organ norepinephrine content after synthesis inhibition with alpha-methyl-para-tyrosine. Sympathetic outflow to the liver and pancreas were slower in B1/6 mice than in control A/J. Glipizide increased sympathetic outflow to the pancreas in both strains of mice, but did not influence outflow to other organs significantly. The results of this study suggest that glipizide can influence central glucoregulatory mechanisms after peripheral administration. [References: 31]
机译：本研究的目的是确定口服降糖药格列吡嗪是否影响易发糖尿病小鼠的交感神经外流。用盐水或格列吡嗪治疗C57BL / 6（易发糖尿病）和抗糖尿病药（A / J），并用α-甲基-对-酪氨酸抑制合成后器官去甲肾上腺素含量下降，确定交感神经外流。 B1 / 6小鼠的肝和胰腺交感神经流出比对照组A / J慢。格列吡嗪在两种小鼠中均增加了向胰腺的交感性流出，但并未显着影响向其他器官的流出。这项研究的结果表明，格列吡嗪可影响外周给药后的中枢糖调节机制。 [参考：31]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号