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首页> 外文期刊>Life sciences >High flaxseed (linseed) diet restores endothelial function in the mesenteric arterial bed of spontaneously hypertensive rats.
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High flaxseed (linseed) diet restores endothelial function in the mesenteric arterial bed of spontaneously hypertensive rats.

机译：高亚麻籽（亚麻籽）饮食可恢复自发性高血压大鼠肠系膜动脉床的内皮功能。

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摘要

The effect of high flaxseed diet (HFD) on blood pressure (BP) and mesenteric arterial bed (MAB) reactivity was studied in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. HFD did not affect BP in either SHR (control, 157 +/- 3; HFD, 153 +/- 3 mmHg) or WKY (control, 114 +/- 2; HFD, 117 +/- 2 mmHg) rats. Increases in perfusion pressure of the endothelium-intact MAB to phenylephrine and norepinephrine were higher (p < 0.05) in SHR than in WKY rats and the HFD failed to alter these responses. Vasorelaxant responses to acetylcholine (ACh) and bradykinin (BK) were greater (p < 0.05) in SHR maintained on HFD compared to SHR on control diet. While HFD also enhanced ACh responses in WKY, the effect was less than in SHR. Responses to sodium nitroprusside (SNP), were similar in all groups. Since ACh and BK-induced responses of the MAB were augmented in SHR on HFD, with no changes in BP, it is suggested that HFD improves endothelial vasorelaxant function through a pressure-independent mechanism.
机译：研究了高亚麻籽饮食（HFD）对自发性高血压大鼠（SHR）和血压正常的Wistar-Kyoto（WKY）大鼠的血压（BP）和肠系膜动脉床（MAB）反应性的影响。在SHR（对照组，157 +/- 3; HFD，153 +/- 3 mmHg）或WKY（对照组，114 +/- 2; HFD，117 +/- 2 mmHg）大鼠中，HFD均不影响BP。与WKY大鼠相比，SHR中内皮完整MAB对去氧肾上腺素和去甲肾上腺素的灌注压力增加更高（p <0.05），而HFD未能改变这些反应。与对照饮食的SHR相比，HFD维持的SHR对乙酰胆碱（ACh）和缓激肽（BK）的血管舒张反应更大（p <0.05）。尽管HFD还增强了WKY中的ACh反应，但其作用小于SHR。在所有组中，对硝普钠（SNP）的反应均相似。由于在HFD的SHR中，ACh和BK诱导的MAB的反应增强，而BP没有变化，因此建议HFD通过压力独立机制改善内皮血管舒张功能。

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