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首页> 外文期刊>Life sciences >Influence of glutamatergic projections to the rostral pontine reticular formation on micturition in rats.
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Influence of glutamatergic projections to the rostral pontine reticular formation on micturition in rats.

机译：谷氨酸能投射对延髓脑桥网状结构对排尿的影响。

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AIMS: We examined the effect of injecting glutamate or a glutamate receptor antagonist into the rostral pontine reticular formation (RPRF) on the micturition reflex in anesthetized rats and conscious rats. MAIN METHOD: Forty-eight female rats were divided into an isovolumetric cystometry group and a continuous cystometry group. Under urethane anesthesia or while conscious, physiological saline, glutamate, or MK-801 (a glutamate receptor antagonist) was injected into the RPRF, and then the changes of bladder activity were examined. KEY FINDINGS: There was no significant change of bladder activity after injection of physiological saline. In anesthetized rats, the injection of either glutamate or MK-801 into the RPRF transiently inhibited bladder contractions. There was a complete recovery of bladder activity 10-20 min after glutamate or MK-801 injection and there were no significant changes of cystometry parameters after the recovery of bladder contractions. In conscious rats, injection of glutamate into the RPRF prolonged the interval between bladder contractions and decreased the baseline bladder pressure. On the other hand, injection of MK-801 into the RPRF caused numerous small bladder contractions, some of which were accompanied by a leakage of a small amount of fluid from around the urethral catheter. SIGNIFICANCE: RPRF neurons receive glutamatergic projections, possibly from the forebrain, and the RPRF inhibits the micturition reflex pathway. RPRF neurons are also regulated by inhibitory interneurons, which receive glutamatergic projections as well. Therefore, the RPRF plays an important role in the regulation of urine storage.
机译：目的：我们研究了在麻醉大鼠和清醒大鼠的鼻翼桥状网状结构（RPRF）中注射谷氨酸或谷氨酸受体拮抗剂对排尿反射的影响。主要方法：将48只雌性大鼠分为等容膀胱测压组和连续膀胱测压组。在尿烷麻醉下或有意识的情况下，将生理盐水，谷氨酸盐或MK-801（谷氨酸盐受体拮抗剂）注入RPRF中，然后检查膀胱活动的变化。主要发现：注射生理盐水后，膀胱活动没有明显变化。在麻醉的大鼠中，向RPRF注射谷氨酸盐或MK-801会暂时抑制膀胱收缩。谷氨酸盐或MK-801注射后10-20分钟，膀胱活动完全恢复，膀胱收缩恢复后膀胱测压参数无明显变化。在有意识的大鼠中，向RPRF注射谷氨酸盐可延长膀胱收缩之间的间隔，并降低基线膀胱压力。另一方面，将MK-801注射到RPRF中会引起许多小的膀胱收缩，其中一些伴有少量尿液从尿道导管周围泄漏。意义：RPRF神经元可能从前脑接受谷氨酸能投射，并且RPRF抑制排尿反射通路。 RPRF神经元也受抑制性中间神经元的调节，这些中间神经元也接受谷氨酸能投射。因此，RPRF在调节尿液储存中起重要作用。

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