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首页> 外文期刊>Life sciences >Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model.
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Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model.

机译：日粮芦荟蛋白，芦荟素或芦荟凝胶在大鼠结肠炎模型中发挥抗炎活性。

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AIMS: Aloe has been a very popular folk remedy for inflammation-related pathological conditions despite the lack of studies reporting its efficacy in vivo. The present study evaluated the anti-inflammatory effects of aloe components (aloin, aloesin and aloe-gel) known to be biologically active in the rat model of colitis. MAIN METHODS: Male Sprague Dawley rats were fed experimental diets for 2 weeks before and during the induction of colitis. Drinking water containing 3% dextran sulfate sodium (DSS) was provided for 1 week to induce colitis. At the end of the experimental period, clinical and biochemical markers were compared. KEY FINDINGS: Plasma leukotriene B(4) (LTB(4)) and tumor necrosis factor-alpha (TNF-alpha) concentrations were significantly decreased in all groups supplemented with aloe components compared to the colitis control group (p<0.05). Animals fed both a 0.1% and 0.5% aloesin supplemented diet showed colonic myeloperoxidase (MPO) activities which were decreased by 32.2% and 40.1%, respectively (p<0.05). Colonic mucosa TNF-alpha and interleukin-1ss (IL-1beta) mRNA expressions were significantly reduced in all animals fed aloin, aloesin, or aloe-gel (p<0.05). SIGNIFICANCE: Dietary supplementation of aloe components ameliorates intestinal inflammatory responses in a DSS-induced ulcerative colitis rat model. In particular, aloesin was the most potent inhibitor. Further studies are required for a more complete understanding of the specific mechanism of the action of these supplements.
机译：目的：尽管缺乏研究报告芦荟具有体内功效，但芦荟一直是治疗炎症相关病理状况的民间疗法。本研究评估了在结肠炎大鼠模型中具有生物活性的芦荟成分（芦荟素，芦荟素和芦荟凝胶）的抗炎作用。主要方法：在诱发结肠炎之前和期间，对雄性Sprague Dawley大鼠进行实验饮食2周。提供含有3％硫酸葡聚糖硫酸钠（DSS）的饮用水1周以诱发结肠炎。在实验期结束时，比较了临床和生化指标。关键发现：与结肠炎对照组相比，补充芦荟成分的所有组血浆白三烯B（4）（LTB（4））和肿瘤坏死因子-α（TNF-alpha）浓度均显着降低（p <0.05）。饲喂0.1％和0.5％芦荟素补充饮食的动物显示结肠髓过氧化物酶（MPO）活性分别降低了32.2％和40.1％（p <0.05）。在喂饲芦荟蛋白，芦荟素或芦荟凝胶的所有动物中，结肠粘膜TNF-α和白介素-1ss（IL-1beta）mRNA表达均显着降低（p <0.05）。意义：饮食中补充芦荟成分可改善DSS诱发的溃疡性结肠炎大鼠模型的肠道炎症反应。特别地，芦荟素是最有效的抑制剂。需要更深入的研究，以更全面地了解这些补品的具体作用机理。

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