...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell biology international. >Sulphate influx in the erythrocytes of normotensive, diabetic and hypertensive patients.
【24h】

Sulphate influx in the erythrocytes of normotensive, diabetic and hypertensive patients.

机译：正常血压，糖尿病和高血压患者红细胞中的硫酸盐流入。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study aimed to show that modifications in intracellular metabolism are implicated in the pathophysiology of diabetes mellitus and essential hypertension. In fact, total magnesium, calcium, sodium and potassium concentrations, measured in the erythrocytes of normotensive, diabetic and hypertensive patients, have given the following results: a lower intracellular potassium concentration in the erythrocytes of diabetic and hypertensive patients than the erythrocytes of normotensive patients and a more elevated sodium, magnesium, calcium concentrations in the erythrocytes of diabetic and hypertensive patients than the normotensive.Because of the importance of Mg(2+) and Ca(2+) in metabolic enzyme regulation and their interaction with both Hb and band 3 protein, we examined SO2-4 kinetic influx in the erythrocytes of normotensive, hypertensive and diabetic patients. The kinetic plots showed different profiles over the three groups and the fluxes were found to be 0.024, 0.061 and 0.072 mmolx(l cellsxmin)(-1) in normotensive, hypertensive and diabetic patients, respectively. We also found that the Vmax and Km of sulphate influx, obtained by Hofstee plots, increased in the erythrocytes of hypertensive and diabetic patients compared with control cells. In contrast, sulphate influx in the erythrocytes of diabetic and hypertensive patients in the presence of Nifedipine, a calcium antagonist, showed no difference either in the rate constants or in the kinetic profiles, compared to the normotensive control subjects.
机译：这项研究旨在表明，细胞内代谢的改变与糖尿病和原发性高血压的病理生理有关。实际上，在血压正常，糖尿病和高血压患者的红细胞中测得的总镁，钙，钠和钾的浓度得出以下结果：与血压正常患者的红细胞相比，糖尿病和高血压患者的红细胞中的细胞内钾浓度更低并且Mg（2+）和Ca（2+）在代谢酶调节及其与Hb和带的相互作用中起着重要的作用，并且糖尿病和高血压患者的红细胞中钠，镁，钙的浓度比正常血压高。在3种蛋白质中，我们检查了正常血压，高血压和糖尿病患者红细胞中的SO2-4动力学流入。动力学图显示了三组患者的不同曲线，在正常血压，高血压和糖尿病患者中，通量分别为0.024、0.061和0.072 mmolx（l cellsxmin）（-1）。我们还发现，与对照组相比，通过Hofstee图获得的硫酸盐流入的Vmax和Km在高血压和糖尿病患者的红细胞中增加。相反，与血压正常对照组相比，在存在硝苯地平（一种钙拮抗剂）的情况下，糖尿病和高血压患者红细胞中的硫酸盐流入量在速率常数或动力学方面均无差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号