• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >EFFECT OF INDOMETHACIN ON THE PITUITARY-ADRENOCORTICAL RESPONSE TO ADRENERGIC STIMULATION
【24h】

EFFECT OF INDOMETHACIN ON THE PITUITARY-ADRENOCORTICAL RESPONSE TO ADRENERGIC STIMULATION

机译：吲哚美辛对垂体-肾上腺皮质刺激对肾上腺刺激的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The role of prostaglandins (PGs) in stimulation of the hypothalamic-pituitary-adrenal (HPA) axis by adrenergic agonists and catecholamines was investigated in nonanesthetized rats. The cyclooxygenase and PGs synthesis inhibitor indomethacin was given systemically or intracerebroventricularly (icy) 15 min prior to phenylephrine (30 mu g), clonidine (10 mu g), and isoproterenol (20 mu g), an alpha(1)-, alpha(2)- and beta-adrenergic receptor agonists, respectively, or noradrenaline (10 mu g) and adrenaline (10 mu g) Indomethacin given ip (2 mg/kg) or icy (10 mu g) almost abolished the increase in corticosterone secretion elicited by phenylephrine, considerably reduced the response to clonidine but did not markedly affect the response to isoproterenol. Pretreatment with indomethacin by either route strongly suppressed the corticosterone response to noradrenaline, but did not substantially affect the hormonal response to adrenaline. The above data indicate that prostaglandins considerably mediate the HPA axis response to central stimulation of alpha(1)- and alpha(2)-, but not beta-adrenergic receptors. They also point to significant involvement of prostaglandins in the noradrenaline-, but not adrenaline-induced HPA response indicating that noradrenaline stimulates the HPA axis predominantly via alpha(1)- and alpha(2)-adrenergic receptors, whereas adrenaline exerts stimulation mainly via beta-adrenergic receptors. [References: 30]
机译：在非麻醉大鼠中研究了前列腺素（PGs）在肾上腺素能激动剂和儿茶酚胺刺激下丘脑-垂体-肾上腺（HPA）轴中的作用。在去氧肾上腺素（30微克），可乐定（10微克）和异丙肾上腺素（20微克），α（1）-，α（ 2）-和β-肾上腺素能受体激动剂，或去甲肾上腺素（10微克）和肾上腺素（10微克）吲哚美辛，腹膜内注射（2 mg / kg）或冰冷（10微克），几乎消除了皮质酮分泌的增加苯肾上腺素的作用明显降低了对可乐定的反应，但没有明显影响对异丙肾上腺素的反应。通过消炎痛的任一途径进行的预处理均能强烈抑制皮质酮对去甲肾上腺素的反应，但基本上不会影响对肾上腺素的激素反应。以上数据表明，前列腺素在介导α（1）-和α（2）-但不是β-肾上腺素能受体的中央刺激方面显着介导HPA轴响应。他们还指出前列腺素显着参与了去甲肾上腺素诱导的HPA反应，但未参与肾上腺素诱导的HPA反应，这表明去甲肾上腺素主要通过α（1）-和α（2）-肾上腺素能刺激HPA轴，而肾上腺素主要通过β刺激肾上腺素能受体。 [参考：30]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号