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首页> 外文期刊>Life sciences >CAMP UPREGULATES THE TRANSPOSABLE ELEMENT MYS-1 - A POSSIBLE LINK BETWEEN SIGNALING AND MOBILE DNA
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CAMP UPREGULATES THE TRANSPOSABLE ELEMENT MYS-1 - A POSSIBLE LINK BETWEEN SIGNALING AND MOBILE DNA

机译：CAMP上调可转移元素MYS-1-信号和移动DNA之间的可能链接

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摘要

Mys represents one of the many families of transposable elements abundant in the mammalian genome. Transposale elements (transposons, retrotransposons, Tr) are best described as ''mobile DNA''. Mechanisms for the transposition process have been well-described and recently two human Tr have been identified as the progenitors of disease producing insertions. A functional role, however, has never been proposed. Studying overexpression of genes induced by cAMP using the technique of subtractive hybridization, a clone Sch. p15 was isolated and sequenced. Computer assisted analysis of the sequence revealed strong homology to mys-1. In a parallel clone cAMP related and cAMP inducible genes were found by this technique. The fact that a mammalian Tr is modulated by the cell's signalling / second messenger system made us hypothesize that transposition may well be under physiological control and that Tr may play physiological roles as e.g, rearranging, reshuffling or programmed erasing of genes. Although methodologically sound, the interpretation of our data remains hypothetical due to the absence of any previous studies on transposition function in eukaryotes. [References: 19]
机译：Mys代表了哺乳动物基因组中丰富的许多可转座因子家族之一。转座子元件（转座子，逆转座子，Tr）最好被描述为“移动DNA”。已经对转座过程的机制进行了充分的描述，并且最近已经确定了两个人类Tr作为产生疾病的插入的祖先。然而，从未提出过功能性角色。使用减性杂交技术（克隆Sch。）研究cAMP诱导的基因的过表达。分离p15并测序。该序列的计算机辅助分析揭示了与mys-1的强同源性。在平行克隆中，通过此技术发现了cAMP相关基因和cAMP诱导基因。哺乳动物Tr被细胞的信号/第二信使系统调节的事实使我们假设转座很可能在生理控制下，并且Tr可能在例如基因的重排，改组或程序擦除中发挥生理作用。尽管从方法论上讲是合理的，但由于以前没有关于真核生物转座功能的研究，因此我们对数据的解释仍然是假设的。 [参考：19]

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