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首页> 外文期刊>Life sciences >Glucose stimulates renin secretion via adrenergic mechanisms in the rat.
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Glucose stimulates renin secretion via adrenergic mechanisms in the rat.

机译：葡萄糖通过大鼠的肾上腺素能刺激肾素分泌。

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To elucidate whether and why glucose directly influences renin secretion, the effect of glucose on renin secretion was investigated in the rat. In an in vivo study, renin activity significantly (p<0.01) increased from the basal value of 7.6 +/- 1.4 to 14.2 +/- 3.2 ng Ang I/ml/hr (mean +/- SD) after intravenous glucose (1.0 g/kg, in 50% glucose solution ) injection. Propranolol (10.5 mg/kg) pretreatment partly abolished the increase in renin activity induced by glucose injection. In an in vitro study, the isolated kidneys of male Wistar rats (200-250 g) were perfused with a basal perfusing medium containing 5.5 mM glucose for 20 min, and then perfused with the medium containing 16.5 mM glucose, 27.5 mM glucose, 5.5 mM glucose + 22 mM mannitol, 27.5 mM glucose + 1 microM phentolamine, or 27.5 mM glucose + 1 microM propranolol for 10 min, respectively. Renin activity was significantly increased from a basal value of 8.1 +/- 4.5 to peak value of 17.9 +/- 3.0 ng Ang I/ml/hr (p<0.01) by 16.5 mM glucose, to 59.0 +/- 10.5 ng Ang I/ml/hr (p<0.005) by 27.5 mM glucose, and to 24.7 +/- 5.8 ng Ang I/ml/hr (p<0.01) by 5.5 mM glucose + 22 mM mannitol. The increase in renin activity in the kidney perfused with 27.5 mM glucose was significantly (p<0.005) higher than that with 16.5 mM glucose or that with 5.5 mM glucose + 22 mM mannitol. The 27.5 mM glucose-stimulated increase in renin activity was not changed by the addition of 1 microM phentolamine, while it was completely abolished by the addition of 1 microM propranolol. These results suggest that glucose has a direct stimulating effect on renin secretion probably through beta-adrenergic mechanisms in the rat.
机译：为了阐明葡萄糖是否以及为什么直接影响肾素的分泌，在大鼠中研究了葡萄糖对肾素分泌的影响。在一项体内研究中，静脉注射葡萄糖（1.0）后，肾素活性显着（p <0.01）从基础值7.6 +/- 1.4增至14.2 +/- 3.2 ng Ang I / ml / hr（平均+/- SD） g / kg，在50％葡萄糖溶液中）注射。普萘洛尔（10.5 mg / kg）预处理部分消除了葡萄糖注射引起的肾素活性增加。在一项体外研究中，将雄性Wistar大鼠（200-250 g）的分离肾脏用含5.5 mM葡萄糖的基础灌注培养基灌注20分钟，然后用含16.5 mM葡萄糖，27.5 mM葡萄糖，5.5的培养基灌注mM葡萄糖+ 22 mM甘露醇，27.5 mM葡萄糖+ 1 microM苯妥拉明或27.5 mM葡萄糖+ 1 microM普萘洛尔持续10分钟。肾素活性通过16.5 mM葡萄糖从基础值8.1 +/- 4.5显着增加到峰值17.9 +/- 3.0 ng Ang I / ml / hr（p <0.01）至59.0 +/- 10.5 ng Ang I / ml / hr（p <0.005）（27.5 mM葡萄糖）和24.7 +/- 5.8 ng Ang I / ml / hr（p <0.01）（5.5 mM葡萄糖+ 22 mM甘露醇）。灌注27.5 mM葡萄糖的肾脏中肾素活性的增加显着（p <0.005）高于灌注16.5 mM葡萄糖或5.5 mM葡萄糖+ 22 mM甘露醇的肾脏。葡萄糖刺激的27.5 mM肾素活性增加未因添加1 microM酚妥拉明而改变，而其因添加1 microM普萘洛尔而被完全消除。这些结果表明葡萄糖可能通过大鼠的β-肾上腺素能机制对肾素分泌具有直接的刺激作用。

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