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Effects of nucleotides on learning and memory in a Morris water maze test in normal and basal forebrain-lesioned rats

机译：莫里斯水迷宫试验中核苷酸对正常和基底前脑损伤大鼠学习和记忆的影响

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摘要

The effects of nucleotides on learning and memory were studied in normal and basal forebrain-lesioned rats using a Morris water maze test. Chronic oral administration of a nucleotide mixture (500 mg/kg), containing an equal weight of the disodium salts of adenosine 5'-monophosphate, guanosine 5'-monophosphate, inosine 5'-monophosphate, cytidine 5'-monophosphate, and uridine 5'-monophosphate facilitated learning acquisition in normal rats. In basal forebrain-lesioned rats, administration of the nucleotide mixture showed a tendency to improve learning acquisition, and memory retrieval. In the biochemical studies, no significant changes were observed in brain choline and acetylcholine levels by treatment with the nucleotide mixture at the doses tested in both normal and basal forebrain-lesioned rats. The nucleotides did not affect the monoaminergic systems in normal rats, but did cause some changes in these systems in basal forebrain-lesioned rats. The present studies indicate that nucleotides ameliorate learning and memory processes in normal rats, but not in basal forebrain-lesioned rats, and they also modulate the activity of the central monoaminergic systems under certain conditions. [References: 27]
机译：使用Morris水迷宫测试研究了正常和基底前脑病变大鼠中核苷酸对学习和记忆的影响。长期口服核苷酸混合物（500 mg / kg），其中包含等重量的腺苷5'-单磷酸，鸟苷5'-单磷酸，肌苷5'-单磷酸，胞苷5'-单磷酸和尿苷5的二钠盐'-单磷酸酯促进正常大鼠的学习习得。在基底前脑损伤的大鼠中，核苷酸混合物的给药显示出改善学习获得和记忆恢复的趋势。在生化研究中，在正常和基底前脑病变大鼠中，通过核苷酸混合物处理的剂量均未观察到脑胆碱和乙酰胆碱水平的显着变化。核苷酸不会影响正常大鼠的单胺能系统，但会在基底前脑病变大鼠中引起这些系统的某些变化。目前的研究表明，核苷酸可以改善正常大鼠的学习和记忆过程，但不能改善基底前脑病变的大鼠，并且在某些条件下还可以调节中央单胺能系统的活性。 [参考：27]

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