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首页> 外文期刊>Cell biology international. >Differential expression of connexin 43 in mouse mammary cells.
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Differential expression of connexin 43 in mouse mammary cells.

机译：连接蛋白43在小鼠乳腺细胞中的差异表达。

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摘要

In this study we have employed suppressive subtractive hybridization (SSH) analysis to investigate differential gene expression in primary mouse mammary epithelial cells (PMMEC) cultured under mildly apoptotic/quiescent and differentiating conditions. Among a small group of genes whose expression was differentially regulated was connexin 43. In vitro, connexin 43 mRNA and protein were detectable in PMMEC cultured under proliferative or mildly apoptotic conditions. The level of connexin 43 mRNA expression in vivo was also investigated. High levels of expression were found to be associated with the periods of greatest glandular plasticity (pubertal expansion of the mammary tree, early pregnancy and during early involution). Thus, terminally differentiated cells in vivo and in vitro did not express connexin 43 mRNA suggesting that connexin 43 expression, and perhaps facilitated gap junction communication, is associated with undifferentiated progenitor cell populations.
机译：在这项研究中，我们采用抑制性消减杂交（SSH）分析来研究在轻度凋亡/静止和分化条件下培养的原代小鼠乳腺上皮细胞（PMMEC）中的差异基因表达。在表达差异受调控的基因中，有一小部分是连接蛋白43。在体外，在增生或轻度凋亡条件下培养的PMMEC中可检测到连接蛋白43 mRNA和蛋白。还研究了体内连接蛋白43 mRNA的表达水平。发现高水平的表达与最大的腺可塑性时期（乳树的青春期扩张，早期妊娠和早期内卷期间）有关。因此，体内和体外的终末分化细胞不表达连接蛋白43 mRNA，表明连接蛋白43的表达，可能是促进间隙连接通讯，与未分化的祖细胞群有关。

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