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首页> 外文期刊>Life sciences >Multiple nitric oxide sources in neurogenic plasma extravasation in rat hindpaw skin.
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Multiple nitric oxide sources in neurogenic plasma extravasation in rat hindpaw skin.

机译：大鼠后足皮肤神经源性血浆外渗中的多种一氧化氮源。

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摘要

The contribution of nitric oxide (NO) to capsaicin-evoked plasma extravasation was studied in rat hindpaw skin. Two inhibitors of NO synthase were used: 7-nitroindazole, with a selectivity for nerve-derived NO, and the L-arginine derivative, N(omega)-nitro-L-arginine (L-NOARG), which is a non-selective inhibitor. Plasma extravasation was induced by intraplantar injection of 5 microg/50 microl capsaicin and measured by the Evans blue leakage technique. Both acute and chronic administration of 7-nitroindazole significantly reduced capsaicin-evoked plasma extravasation in rat hind-paw skin, whereas L-NOARG enhanced it. This enhancement was abolished non-stereospecifically by either L- or D-arginine. Our results suggest that NO production from different sources yields a complex action in maintaining the endothelial integrity in neurogenic plasma extravasation.
机译：一氧化氮（NO）对辣椒素引起的血浆外渗的作用在大鼠后足皮肤中进行了研究。使用了两种NO合酶抑制剂：对神经源性NO具有选择性的7-硝基吲唑和非选择性的L-精氨酸衍生物N（ω）-硝基-L-精氨酸（L-NOARG）抑制剂。血浆外渗是通过足底注射5微克/ 50微升辣椒素诱导的，并通过伊文思蓝漏技术进行测量。急性和慢性给予7-硝基吲唑均可显着降低辣椒素引起的大鼠后爪皮肤血浆外渗，而L-NOARG则可增强血浆外渗。 L-或D-精氨酸非立体地消除了这种增强。我们的结果表明，不同来源的NO产生在神经源性血浆外渗中维持内皮完整性方面产生复杂的作用。

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