• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Attenuation of the magnitude of suckling-induced prolactin release with advancing lactation: mechanisms.
【24h】

Attenuation of the magnitude of suckling-induced prolactin release with advancing lactation: mechanisms.

机译：哺乳期泌乳引起乳汁催乳素释放的幅度减弱：机制。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To study why suckling-induced plasma prolactin levels decline in magnitude with advancing lactation, we examined prolactin release in lactating rats following suckling and pharmacologic manipulations during early, mid- and late lactation. On day 2 of lactation, litters were adjusted to 8 pups. On day 3, dams were implanted with an atrial catheter and experiments were conducted on lactation days 5, 11 and 17. To examine suckling-induced prolactin release, pups were removed at 0800 h, an extension was attached to the catheter at 1100 h, and pups returned to dams at 1200 h. Blood samples were obtained before, and at 10, 30, 60, 90 and 120 min after suckling started. Prolactin responses to sulpiride and thyrotropin releasing hormone (TRH) administration were studied in lactating rats separated from their litters for 4 hours. Blood samples were obtained before, and at 10, 30, 60 and 90 min after sulpiride (10 or 40 micrograms/kg BW) and 5, 10, 20 and 30 min after TRH (1 or 4 micrograms/kg BW) in rats pretreated with sulpiride. Prolactin release in response to suckling, administration of sulpiride or sulpiride and TRH diminished as lactation advanced. From these results, we conclude that refractoriness in anterior pituitary lactrotropes to prolactin-releasing stimuli is at least partially responsible for the decline in suckling-induced prolactin release with advancing lactation.
机译：为了研究为什么哺乳诱导的血浆催乳素水平会随着泌乳的增加而下降，我们在哺乳的早期，中期和晚期进行了哺乳和药物处理后，研究了泌乳大鼠中催乳素的释放。哺乳第2天，将幼仔调整为8只幼崽。在第3天，将大坝植入心房导管，并在哺乳期的第5、11和17天进行实验。为检查乳汁诱导的催乳激素释放，在0800 h取出幼崽，在1100 h将导管延长，幼犬在1200小时返回大坝。在开始哺乳之前和之后的10、30、60、90和120分钟获取血液样本。在哺乳期大鼠从其产仔中分离了4小时后，研究了催乳素对舒必利和促甲状腺激素释放激素（TRH）的反应。在预处理的大鼠中，在磺必利（10或40微克/千克体重）之前，之后10、30、60和90分钟以及在TRH（5或4微克/千克体重）之后5、10、20和30分钟时获取血样与舒必利。随着哺乳，泌乳，舒必利或舒必利的催乳素释放和TRH随着泌乳的进行而减少。从这些结果，我们得出结论，垂体前叶促乳酸对催乳激素释放刺激的难治性至少部分负责随着哺乳期哺乳引起的催乳素释放的下降。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号