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首页> 外文期刊>Life sciences >Morphine antinociception in the non-hibernating and hibernating states of the ground squirrel (Citellus lateralis).
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Morphine antinociception in the non-hibernating and hibernating states of the ground squirrel (Citellus lateralis).

机译：在地松鼠（Citelluslateralis）处于非冬眠和冬眠状态时的吗啡抗伤害感受。

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Previous work in our laboratory demonstrated a significant reduction in the development of morphine physical dependence during hibernation, suggesting a major change in the ability of morphine to act on the central nervous system (CNS) during this naturally altered state. To further investigate the pharmacological actions of morphine during the hibernating (H) state, the present study recorded skin-twitch response (STR) latency as a measure of morphine antinociception in the golden-mantled ground squirrel (Citellus lateralis) during the non-hibernating (NH) and H states. Our results revealed that morphine antinociception continued to develop in hibernation. Moreover, the magnitude of antinociception displayed was greater during the H state than in the NH state. Tolerance to morphine's antinociceptive effects developed in both states as well. The results of the present study indicate that the hibernation-related reduction in the development of morphine dependence represents a selective, rather than a general, suppression of the CNS pharmacological actions of morphine during the H state.
机译：我们实验室以前的工作表明，在休眠状态下，吗啡对身体的依赖性显着降低，这表明在这种自然改变的状态下，吗啡作用于中枢神经系统（CNS）的能力发生了重大变化。为了进一步研究吗啡在冬眠（H）状态下的药理作用，本研究记录了皮肤抽搐反应（STR）潜伏期，作为非冬眠期金golden鼠（Citelluslateralis）中吗啡抗伤害感受的量度（NH）和H状态。我们的结果表明吗啡抗伤害感受在冬眠中继续发展。而且，在H状态下显示的抗伤害感受的幅度大于在NH状态下。在这两种状态下，对吗啡的镇痛作用的耐受性也都有发展。本研究的结果表明，与休眠有关的吗啡依赖发展的减少代表了在H状态期间对吗啡的CNS药理作用的选择性而非一般抑制。

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