IN VIVO EFFECTS OF SUPERANTIGENS [Review]

Blackman MA.; Woodland DL.

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IN VIVO EFFECTS OF SUPERANTIGENS [Review]

机译：超级抗原的体内作用[综述]

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Superantigens are potent immunostimulatory molecules that activate both T cells and antigen presenting cells. The consequences of superantigen exposure range from induction of T cell proliferation, massive cytokine release and systemic shock to immunosuppression and tolerance. Superantigens have been directly implicated in a number of human conditions including food poisoning and toxic shock. In addition, there is evidence to suggest that superantigens are involved in the initiation of autoimmunity, and the immune dysfunction associated with HIV infection. Because of their possible role in human disease, and their potential use in immune therapy, it is important that we more completely understand the in vivo effects of superantigens. [References: 197]

机译：超抗原是激活T细胞和抗原呈递细胞的有效免疫刺激分子。暴露于超抗原的后果从诱导T细胞增殖，大量细胞因子释放和全身性休克到免疫抑制和耐受性不等。超抗原直接与许多人类疾病有关，包括食物中毒和中毒性休克。另外，有证据表明超抗原参与了自身免疫的启动以及与HIV感染有关的免疫功能障碍。由于它们在人类疾病中的可能作用及其在免疫疗法中的潜在用途，因此重要的是，我们必须更全面地了解超抗原的体内作用。 [参考：197]

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《Life sciences》 |1995年第19期|共19页
作者
Blackman MA.; Woodland DL.;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Superantigen; T cell; Tolerance; Apoptosis; Cytokines; Systemic shock; Autoimmunity; Infectious disease; T-cell-receptor; Staphylococcal-enterotoxin-b; Major histocompatibility complex; Toxic shock syndrome; Class-ii molecules; Experimental autoimmune encephalomyelitis; Experimental allergic encephalomyelitis; Cytokine gene-expression; Chain transgenic mice; Tumor virus-infection;

机译：超抗原;T细胞;耐受性;凋亡;细胞因子;全身性休克;自身免疫;传染病;T细胞受体;葡萄球菌-肠毒素-b;主要组织相容性复合物;毒性休克综合征;II类分子;实验性自身免疫性脑脊髓炎;实验性变态反应性脑脊髓炎脑脊髓炎;细胞因子基因表达;链条转基因小鼠;肿瘤病毒感染;

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1. IN VIVO EFFECTS OF SUPERANTIGENS [Review] [J] . Blackman MA., Woodland DL. Life sciences . 1995,第19期

机译：超级抗原的体内作用[综述]
2. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects [Review] [J] . Morgan WF. Radiation Research: Official Organ of the Radiation Research Society . 2003,第5期

机译：暴露于电离辐射中的非目标性和延迟效应：II。辐射引起的基因组不稳定性和体内旁观者效应，致胶因子和转基因效应[综述]
3. Deleterious effects of whole-body vibration on the spine:A review of in vivo,ex vivo,and in vitro models [J] . Folly Patterson, Raheleh Miralami, Keith E.Tansey, 动物模型与实验医学（英文） . 2021,第002期

机译：全身振动对脊柱的有害影响：体内，前体内和体外模型的评论
4. IN VIVO EFFECTS AND EX VIVO CHARACTERISTICS FOLLOWING IMPLANTATION OF A TISSUE ENGINEERED URETHRAL WRAP [C] . Donna J. Haworth, Minoru Miyazato, Akira Furuta, ASME summer bioengineering conference;SBC2008 . 2009

机译：植入组织工程化尿道创口后的体内效应和体外特征
5. Generation and partial characterization of a regulatory T cell phenotype following repeated in vivo treatment with the staphylococcal superantigen toxic shock syndrome toxin-1. [D] . Cameron, Scott. 2005

机译：葡萄球菌超抗原毒性休克综合征毒素-1反复体内治疗后，调节性T细胞表型的生成和部分表征。
6. In vivo effects of a recombinant vaccinia virus expressing a mouse mammary tumor virus superantigen. [O] . C Krummenacher, H Diggelmann, H Acha-Orbea 1996

机译：表达小鼠乳腺肿瘤病毒超抗原的重组牛痘病毒的体内作用。
7. Streptococcal toxic shock-like syndrome: evidence of superantigen activity and its effects on T lymphocyte subsets in vivo. [O] . Michie, C, Scott, A, Cheesbrough, J, 2008

机译：链球菌中毒性休克样综合征：体内超抗原活性及其对T淋巴细胞亚群的影响的证据。

IN VIVO EFFECTS OF SUPERANTIGENS [Review]

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