In vitro and in vivo stability of new multilamellar vesicles.

Freund O; Amedee J; Roux D; Laversanne R

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In vitro and in vivo stability of new multilamellar vesicles.

机译：新的多层囊泡的体外和体内稳定性。

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Factors affecting multilamellar vesicles transport to the blood compartment after oral administration to rats were evaluated first in vitro. A high entrapment of protein A was obtained when the vesicles were prepared by shearing a lyotropic lamellar phase composed of soybean phosphatidylcholine, cholesterol and polyoxyethylene alcohol (C12H25(OCH2CH2)4OH) as neutral detergent. In vitro tests showed that these vesicles (spherulites) were stabled in 50% of fetal calf serum, in acidic (pH 3) or basic (pH 10) buffers, in pancreatin but are partially lysed in 20mM bile salts. Oral administration of spherulites entrapping 111In-NTA in fasting rats showed a increase of radioacticivity in blood. This could be explained by passage of some spherulites in the enterocytes.

机译：首先在体外评估影响大鼠口服给药后多层囊泡转运至血室的因素。当通过剪切由大豆磷脂酰胆碱，胆固醇和聚氧乙烯醇（C12H25（OCH2CH2）4OH）组成的溶致层状相来剪切囊泡时，可以高度捕获蛋白质A。体外测试表明，这些囊泡（球晶）在50％的胎牛血清中，在酸性（pH 3）或碱性（pH 10）缓冲液，胰酶中稳定，但在20mM胆汁盐中部分溶解。在禁食大鼠中口服包埋111In-NTA的球晶显示血液中放射性增加。这可以通过一些球细胞在肠上皮细胞中通过来解释。

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《Life sciences》 |2000年第4期|共9页
作者
Freund O; Amedee J; Roux D; Laversanne R;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Liposomes; Staphylococcal Protein A; Bile Acids and Salts; Drug Carriers; 脂质体; 葡萄球菌蛋白质A;

机译：Liposomes;Staphylococcal Protein A;Bile Acids and Salts;Drug Carriers;脂质体;葡萄球菌蛋白质A;

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1. 菜豆下胚轴质膜微囊和液泡膜微囊体外热稳定性的研究 [J] . 刘箭, 杨晓贺植物学报：英文版 . 1996,第005期
2. In vitro and in vivo stability of new multilamellar vesicles. [J] . Freund O, Amedee J, Roux D, Life sciences . 2000,第4期

机译：新的多层囊泡的体外和体内稳定性。
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4. Differential ability of cholesterol-enriched and gel phase domains to resist benzyl alcohol-induced fluidization in multilamellar lipid vesicles. [J] . Maula T, Westerlund B, Slotte JP Biochimica et biophysica acta. Biomembranes . 2009,第11期

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5. Kinetics in vitro versus in vivo in the context of quantitative in vitro in vivo extrapolation (QIVIVE) [C] . Nynke Kramer Annual conference of the International Society of Exposure Science . 2016

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6. Evaluation of In-Vitro Methods That Can Predict In-Vivo Stability of Liposomes [D] . Gurrala, Harshavardan Reddy 2017

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7. Effects of the anesthetic dibucaine on the kinetics of the gel-liquid crystalline transition of dipalmitoylphosphatidylcholine multilamellar vesicles. [O] . W W van Osdol, Q Ye, M L Johnson, 1992

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8. Effects of the anesthetic dibucaine on the kinetics of the gel-liquid crystalline transition of dipalmitoylphosphatidylcholine multilamellar vesicles. [O] . van Osdol, W W, Ye, Q, Johnson, M L, 1992

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In vitro and in vivo stability of new multilamellar vesicles.

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