• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in their recovery from stress-induced ulcers.
【24h】

Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in their recovery from stress-induced ulcers.

机译：对阿扑吗啡敏感和对阿扑吗啡不敏感的Wistar大鼠从应激性溃疡的恢复中有所不同。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of the present study was to investigate the effects of restraint-in-water-stress on gastric ulcerations in two fundamentally different types of animals: the apomorphine-susceptible (APO-SUS) and apomorphine-unsusceptible (APO-UNSUS) rats. APO-SUS and APO-UNSUS do not only differ in their susceptibility to the dopamine agonist apomorphine, but also in stress-induced release of mesolimbic dopamine and corticosterone. All three factors are known to either predict or be involved in gastric ulceration. The results showed that immediately after the stressor the ulcerations in APO-SUS and APO-UNSUS rats were not line-specific. On the contrary, the recovery from gastric ulceration varied between both types of rat: APO-SUS rats did not show any sign of recovery after 6 hours whereas APO-UNSUS rats significantly recovered during the period of 0-6 hr after the stressor. It is hypothesised that this difference is due to the fact that APO-UNSUS rats are characterised by a less and shorter-lasting stress-induced increase of corticosterone. This study provides evidence that the pathological effects of exposure to stressors significantly differ between APO-SUS and APO-UNSUS rats and that genetic factors may direct the process of recovering from ulcers.
机译：本研究的目的是研究在两种根本不同类型的动物中，水压约束对胃溃疡的影响：对阿扑吗啡敏感的动物（APO-SUS）和对阿扑吗啡敏感的动物（APO-UNSUS）。 APO-SUS和APO-UNSUS不仅在对多巴胺激动剂阿扑吗啡的敏感性上有所不同，而且在应激诱导的中脑边缘多巴胺和皮质酮释放方面也有所不同。已知所有这三个因素均可预测或参与胃溃疡。结果表明，在应激源后，APO-SUS和APO-UNSUS大鼠的溃疡不是线特异性的。相反，在两种类型的大鼠中，从胃溃疡的恢复均不同：APO-SUS大鼠在6小时后未显示任何恢复迹象，而APO-UNSUS大鼠在应激后0-6小时内显着恢复。假设该差异是由于以下事实：APO-UNSUS大鼠的特点是应激诱导的皮质酮增加较少且持续时间较短。这项研究提供的证据表明，暴露于应激源的病理影响在APO-SUS和APO-UNSUS大鼠之间存在显着差异，并且遗传因素可能指导溃疡的恢复过程。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号