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首页> 外文期刊>Life sciences >Protective effects of methanol extract of Acori graminei rhizoma and Uncariae Ramulus et Uncus on ischemia-induced neuronal death and cognitive impairments in the rat.
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Protective effects of methanol extract of Acori graminei rhizoma and Uncariae Ramulus et Uncus on ischemia-induced neuronal death and cognitive impairments in the rat.

机译：ori草和and属的甲醇提取物对大鼠缺血性神经元死亡和认知障碍的保护作用。

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摘要

Acori graminei rhizoma (AGR) and Uncariae Ramulus et Uncus (URE) have been widely used as herbal medicine against ischemia. In order to investigate whether AGR and URE influenced cerebral ischemia-induced neuronal and cognitive impairments, we examined the effect of AGR and URE on ischemia-induced cell death in the striatum, cortex and hippocampus, and on the impaired learning and memory in the Morris water maze and radial eight-arm maze in rats. After middle cerebral artery occlusion (MCAO) for 2 h, rats were administered saline, AGR or URE (100 mg/kg, p.o.) daily for three weeks, followed by their training to the tasks. In the water maze test, the animals were trained to find a platform in a fixed position during 6 days and then received a 60-s probe trial in which the platform was removed from the pool on the 7th day. In the radial eight-arm maze, animals were tested six times per week for 1 week. Rats with ischemic insults showed impaired learning and memory on the tasks. Pretreatment with AGR and URE produced a significant improvement in escape latency to find the platform in the Morris water maze and in the number of choice errors in the radial arm maze test. Consistent with behavioral data, pretreatments with AGR and URE significantly reduced ischemia-induced cell death in the hippocampal CA1 area. These results demonstrated that AGR and URE have a protective effect against ischemia-induced neuronal loss and learning and memory damage. Our studies suggest that AGR and URE may be useful in the treatment of vascular dementia.
机译：禾本科草根（AGR）和钩藤（Runculus et Uncus）（URE）已被广泛用作抗缺血的草药。为了研究AGR和URE是否影响脑缺血诱导的神经元和认知障碍，我们检查了AGR和URE对纹状体，皮质和海马缺血诱导的细胞死亡以及莫里斯学习和记忆障碍的影响水迷宫和放射状八臂迷宫的大鼠。大脑中动脉闭塞（MCAO）2小时后，每天给大鼠注射生理盐水，AGR或URE（100 mg / kg，p.o.），持续三周，然后对其进行训练。在水迷宫测试中，训练动物在6天内找到固定位置的平台，然后接受60 s探针试验，在第7天将其从水池中移出。在the八臂迷宫中，每周对动物进行六次测试，共1周。患有缺血性损伤的大鼠对任务的学习和记忆能力受损。用AGR和URE进行预处理可以显着改善逃生潜伏期，从而在莫里斯水迷宫中找到平台，并在the臂迷宫测试中选择错误次数增加。与行为数据一致，AGR和URE预处理可显着减少海马CA1区缺血诱导的细胞死亡。这些结果表明，AGR和URE对缺血引起的神经元丢失和学习记忆障碍具有保护作用。我们的研究表明，AGR和URE可能对血管性痴呆的治疗有用。

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