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Effect of propolis on human cartilage and chondrocytes.

机译：蜂胶对人软骨和软骨细胞的影响。

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Propolis, a natural product derived from plant resins collected by the honeybees, has been used for thousands of years in folk medicine for several purposes. The extract that contains amino acids, phenolic acids, phenolic acid esters, flavonoids, cinnamic acid, terpenes and caffeic acid, possesses several biological activities such as anti-inflammatory, immunostimulatory, anti-viral and anti-bacterial. In this study, we assay the effects of propolis extract on the production of key molecules released during chronic inflammatory events as nitric oxide (NO) and glycosaminoglycans (GAGs) in cultures of human cartilaginous tissues and chondrocytes, stimulated with interleukin-1beta (IL-1beta). We observed that this natural compound and its active principle, caffeic acid phenethyl ester (CAPE), were able to contrast the harmful effects of IL-1beta.Our data clearly demonstrated the protective action of propolis in cartilage alteration, that appears greater than that elicited by indomethacin, commonly employed in joint diseases.
机译：蜂胶是从蜜蜂收集的植物树脂中提取的天然产物，已经在民间医学中用于多种用途已有数千年的历史了。含有氨基酸，酚酸，酚酸酯，类黄酮，肉桂酸，萜烯和咖啡酸的提取物具有多种生物活性，例如抗炎，免疫刺激，抗病毒和抗菌。在这项研究中，我们分析了蜂胶提取物对在慢性炎症事件中释放的关键分子产生的影响，这些关键分子是在白细胞介素-1β（IL- 1beta）。我们观察到这种天然化合物及其有效成分咖啡酸苯乙酯（CAPE）能够与IL-1beta的有害作用形成对比。我们的数据清楚地证明了蜂胶在软骨改变中的保护作用，其作用远大于诱导的作用。吲哚美辛通常用于关节疾病。

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