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首页> 外文期刊>Life sciences >SKI306X, an oriental herbal mixture, suppresses gastric leukotriene B4 synthesis without causing mucosal injury and the diclofenac-induced gastric lesions.
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SKI306X, an oriental herbal mixture, suppresses gastric leukotriene B4 synthesis without causing mucosal injury and the diclofenac-induced gastric lesions.

机译：SKI306X是一种东方草药混合物，可抑制胃白三烯B4的合成，而不会引起粘膜损伤和双氯芬酸引起的胃部病变。

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摘要

SKI306X compound is a herbal mixture. This plant was in oriental medicine and was clinically approved for the treatment of osteoarthritis (OA) in Korea. SKI306X was previously found to have anti-inflammatory, analgesic and cartilage protective effects in several experimental models. In this study, SKI306X was investigated for its gastro-sparing effects on the gastric mucosa comparing with those of diclofenac, a conventional NSAID, and celecoxib, a cyclooxygenase-2 (COX-2) specific inhibitor. To investigate acute gastric damaging properties of SKI306X, the stomach of the animals was histologically and immuno-histochemically examined after single or repeated administration, and SKI306X demonstrated excellent gastric tolerability. SKI306X did not cause significant gastric irritation, erosion, or ulceration up to the orally administered dose of 2 g/kg and the intraperitoneal (i.p.) dose of 125 mg/kg. In contrast, diclofenac caused mucosal erosion, ulceration and bleeding at clinically effective doses. To determine the mode of gastro-sparing action, eicosanoid synthesis was examined in gastric mucosa and blood. SKI306X significantly decreased gastric and blood leukotriene B(4) (LTB(4)) production. However, SKI306X showed either no effect or a slight increase in levels of prostaglandin E(2) (PGE(2)). In addition, gastro-protective effects of SKI306X were exhibited by suppressing diclofenac-induced erosion and ulceration of gastric mucosa in a rat model and the possible mechanism of these effects were investigated. These studies demonstrated that SKI306X did not produce any significant damage up to dose of 2 g/kg and was effective in significantly protecting the damage associated to diclofenac-induced gastric ulcerations. SKI306X could spare the gastric mucosa through significantly suppressing gastric leukotriene (LT) synthesis.
机译：SKI306X化合物是草药混合物。该植物属于东方医学，在韩国已被临床批准用于治疗骨关节炎（OA）。先前在多个实验模型中发现SKI306X具有抗炎，镇痛和软骨保护作用。在这项研究中，与传统的NSAID双氯芬酸和环氧合酶2（COX-2）特异性抑制剂celecoxib相比，研究了SKI306X对胃粘膜的保胃作用。为了研究SKI306X的急性胃损伤特性，在单次或重复给药后，对动物的胃进行了组织学和免疫组化检查，SKI306X表现出优异的胃耐受性。在口服2 mg / kg剂量和腹膜内（i.p.）剂量125 mg / kg之前，SKI306X不会引起明显的胃刺激，糜烂或溃疡。相反，双氯芬酸以临床有效剂量引起粘膜糜烂，溃疡和出血。为了确定保胃作用的方式，在胃粘膜和血液中检查类花生酸合成。 SKI306X大大减少了胃和血液白三烯B（4）（LTB（4））的生产。但是，SKI306X显示没有影响或前列腺素E（2）（PGE（2））的水平略有增加。此外，在大鼠模型中，SKI306X的胃保护作用通过抑制双氯芬酸诱导的胃粘膜糜烂和溃疡发挥作用，并研究了这些作用的可能机制。这些研究表明，SKI306X直至2 g / kg的剂量都不会产生任何明显的损害，并且可以有效地保护与双氯芬酸诱导的胃溃疡相关的损害。 SKI306X可以通过显着抑制胃白三烯（LT）合成来避免胃粘膜粘连。

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