Cholesterol selectively enhances in vitro latex-specific IgE production in atopic dermatitis patients with latex allergy.

Kimata H

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Cholesterol selectively enhances in vitro latex-specific IgE production in atopic dermatitis patients with latex allergy.

机译：胆固醇在患有乳胶过敏的特应性皮炎患者中选择性增强体外乳胶特异性IgE的产生。

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Effect of cholesterol on in vitro latex-specific IgE production by mononuclear cells from atopic dermatitis patients with latex allergy. Cholesterol enhanced latex-specific IgE production in a dose-dependent fashion, and maximal enhancement was achieved at 1 microg/ml. In contrast, cholesterol had no effect on latex -specific IgA or IgG4 production. Study for cytokine production revealed that cholesterol decreased latex-induced production of IFN-gamma and IL-12, while it increased latex-induced production of IL-4, IL-10 and IL-13. These results indicate that cholesterol skews cytokine pattern toward Th2 type. Collectively, cholesterol may increase allergen-specific IgE production, which may in turn aggravate allergic symptoms.

机译：胆固醇对患有乳胶过敏的特应性皮炎患者的单核细胞对体外乳胶特异性IgE产生的影响。胆固醇以剂量依赖的方式增强了乳胶特异性IgE的产生，在1微克/毫升时达到了最大的增强。相反，胆固醇对乳胶特异性IgA或IgG4的产生没有影响。细胞因子产生的研究表明，胆固醇降低了乳胶诱导的IFN-γ和IL-12的产生，而胆固醇增加了乳胶诱导的IL-4，IL-10和IL-13的产生。这些结果表明胆固醇使细胞因子模式偏向Th2型。总的来说，胆固醇可能会增加特定于过敏原的IgE的产生，进而加剧过敏症状。

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《Life sciences》 |2005年第13期|共6页
作者
Kimata H;
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正文语种 eng
中图分类基础医学;
关键词
Cholesterol; Dermatitis; Atopic; Immunoglobulin E; Latex Hypersensitivity; 胆固醇; 皮炎; 特应性;

机译：Cholesterol;Dermatitis;Atopic;Immunoglobulin E;Latex Hypersensitivity;胆固醇;皮炎;特应性;

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1. Cholesterol selectively enhances in vitro latex-specific IgE production in atopic dermatitis patients with latex allergy. [J] . Kimata H Life sciences . 2005,第13期

机译：胆固醇在患有乳胶过敏的特应性皮炎患者中选择性增强体外乳胶特异性IgE的产生。
2. Listening to mozart reduces allergic skin wheal responses and in vitro allergen-specific IgE production in atopic dermatitis patients with latex allergy. [J] . Kimata H Behavioral Medicine . 2003,第1期

机译：听莫扎特疗法可减轻患有乳胶过敏的特应性皮炎患者的皮肤过敏反应和体外过敏原特异性IgE的产生。
3. Enhancement of allergic skin wheal responses and in vitro allergen-specific IgE production by computer-induced stress in patients with atopic dermatitis. [J] . Kimata H Brain, Behavior, and Immunity . 2003,第2期

机译：通过计算机诱发的特应性皮炎患者增强过敏性皮肤呼吸反应和体外变应原特异性IgE产生。
4. Serum anti-Staphylococcus pseudintermedius IgE and IgG antibodies in dogs with atopic dermatitis and nonatopic dogs [C] . Jennifer Bexley, Timothy J. Nuttallt, Bruce Hammerberg, World Congress of Veterinary Dermatology . 2013

机译：血清抗葡萄球菌伪霉菌和IgG抗体在狗的特应性皮炎和非植物犬
5. IgE anti-HIV-1 in serum of HIV-1 infected children inhibits HIV-1 production in vitro and IgE mediates cytotoxicity against lymphoma cells expressing HIV-1 and peripheral blood mononuclear cells from an HIV-1 seropositive patient [D] . Bluth, Martin Heath. 1997

机译：HIV-1感染儿童血清中的IgE抗HIV-1抑制了HIV-1的体外产生，IgE介导了对HIV-1血清反应阳性患者表达HIV-1的淋巴瘤细胞和外周血单核细胞的细胞毒性
6. Anti-Malassezia-Specific IgE Antibodies Production in Japanese Patients with Head and Neck Atopic Dermatitis: Relationship between the Level of Specific IgE Antibody and the Colonization Frequency of Cutaneous Malassezia Species and Clinical Severity [O] . Enshi Zhang, Takafumi Tanaka, Mami Tajima, 2011

机译：日本头颈部特应性皮炎患者抗马拉色氏菌特异性IgE抗体的产生：特异性IgE抗体水平与皮肤马拉色菌属定植频率与临床严重性之间的关系
7. Anti-Malassezia-Specific IgE Antibodies Production in Japanese Patients with Head and Neck Atopic Dermatitis: Relationship between the Level of Specific IgE Antibody and the Colonization Frequency of Cutaneous Malassezia Species and Clinical Severity [O] . Zhang, Enshi, Tanaka, Takafumi, Tajima, Mami, 2011

机译：日本头颈部特应性皮炎患者抗马拉色氏菌特异性IgE抗体的产生：特异性IgE抗体水平与皮肤马拉色菌属物种定植频率与临床严重性之间的关系

Cholesterol selectively enhances in vitro latex-specific IgE production in atopic dermatitis patients with latex allergy.

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