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首页> 外文期刊>Life sciences >Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats
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Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats

机译：芙蓉，迷迭香和丹参对硫唑嘌呤致大鼠毒性的保护作用

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As an anti-metabolite, Azathioprine inhibits the de novo and salvage pathways of purine synthesis. Intraperitoneal injection of this drug results in not only lymphocyte suppression but also toxicity to bone marrow, gastrointestinal tract, and liver. This Azathioprine-induced hepatotoxicity was found to be associated with oxidative damage. Plants with antioxidative properties have been traditionally used to prevent diseases associated with free radicals. In this report, we used water extracts of three herbal plants that have been commonly used for treating many illnesses (Hibiscus sabdariffa, Rosmarinus officinalis and Salvia officinalis). Here we show their novel hepatoprotective effects against Azathioprine-induced hepatotoxicity in rats. Typically, administration of Azathioprine induces oxidative stress through depleting the activities of antioxidants and elevating the level of malonialdehyde in liver. This escalates levels of alanine aminotransferase, and aspartate aminotranferase in serum. Pretreatment with any of the three herbal plants used in this investigation proved to have a protective effect against Azathioprine-induced hepatotoxicity. Animals pretreated with water extracts from any of the three herbs under investigation not only failed to show necrosis of the liver after azathioprine administration, but also retained livers that, for the most part, were histologically normal. In addition, these herbs blocked the induced elevated levels of alanine aminotransferase and aspartate aminotranferase in serum. The Azathioprine-induced oxidative stress was relieved to varying degrees by the examined herbal extracts. This effect was evident through reducing malonialdehyde levels and releasing the inhibitory effect of Azathioprine on the activities of glutathione, catalase and superoxide dismutase. To our knowledge, this report is the first that shows hepatoprotective effects of Hibiscus, Rosmarinus and Salvia species against Azathioprine-induced acute liver damage. (c) 2005 Elsevier Inc. All rights reserved.
机译：作为抗代谢物，硫唑嘌呤抑制嘌呤合成的从头和挽救途径。腹膜内注射该药物不仅导致淋巴细胞抑制，而且对骨髓，胃肠道和肝脏产生毒性。发现硫唑嘌呤诱导的肝毒性与氧化损伤有关。传统上，具有抗氧化特性的植物可用于预防与自由基有关的疾病。在本报告中，我们使用了三种草药的水提取物，这些草药通常用于治疗多种疾病（芙蓉，迷迭香和丹参）。在这里，我们显示了它们对大鼠硫唑嘌呤诱导的肝毒性的新型肝保护作用。通常，硫唑嘌呤的给药通过消耗抗氧化剂的活性并提高肝脏中丙二醛的水平来诱导氧化应激。这会升高血清中丙氨酸转氨酶和天冬氨酸转氨酶的水平。事实证明，用本研究中的三种草药植物中的任何一种进行预处理，都具有抗硫唑嘌呤诱导的肝毒性的保护作用。用接受研究的三种草药中的任何一种提取的水提取物预处理的动物不仅在硫唑嘌呤给药后未显示肝脏坏死，而且保留了大部分在组织学上正常的肝脏。另外，这些草药阻止了血清中丙氨酸氨基转移酶和天冬氨酸氨基转移酶的诱导水平升高。通过检查的草药提取物，硫唑嘌呤诱导的氧化应激得到不同程度的缓解。通过降低丙二醛水平和释放硫唑嘌呤对谷胱甘肽，过氧化氢酶和超氧化物歧化酶活性的抑制作用，可以明显看出这种作用。据我们所知，该报告是第一个显示木槿，迷迭香和丹参物种对硫唑嘌呤引起的急性肝损伤的保肝作用的报告。 （c）2005 Elsevier Inc.保留所有权利。

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