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Drug discovery from medicinal plants.

机译：从药用植物中发现药物。

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Current research in drug discovery from medicinal plants involves a multifaceted approach combining botanical, phytochemical, biological, and molecular techniques. Medicinal plant drug discovery continues to provide new and important leads against various pharmacological targets including cancer, HIV/AIDS, Alzheimer's, malaria, and pain. Several natural product drugs of plant origin have either recently been introduced to the United States market, including arteether, galantamine, nitisinone, and tiotropium, or are currently involved in late-phase clinical trials. As part of our National Cooperative Drug Discovery Group (NCDDG) research project, numerous compounds from tropical rainforest plant species with potential anticancer activity have been identified. Our group has also isolated several compounds, mainly from edible plant species or plants used as dietary supplements, that may act as chemopreventive agents. Although drug discovery from medicinal plants continues to provide an important source ofnew drug leads, numerous challenges are encountered including the procurement of plant materials, the selection and implementation of appropriate high-throughput screening bioassays, and the scale-up of active compounds.
机译：目前，从药用植物中发现药物的研究涉及将植物，植物化学，生物和分子技术相结合的多方面方法。药用植物药物的发现继续为抵抗包括癌症，HIV / AIDS，阿尔茨海默氏病，疟疾和疼痛在内的各种药理学目标提供了重要的新线索。几种植物来源的天然产物药物或者最近已引入美国市场，包括蒿甲醚，加兰他敏，尼替尼酮和噻托溴铵，或者目前正参与后期临床试验。作为我们国家合作药物发现小组（NCDDG）研究项目的一部分，已经鉴定出来自热带雨林植物物种的许多具有潜在抗癌活性的化合物。我们的小组还分离了几种化合物，主要是从食用植物物种或用作膳食补充剂的植物中分离出来的，这些化合物可能起到化学预防剂的作用。尽管从药用植物中发现药物仍然是提供新药线索的重要来源，但仍遇到许多挑战，包括植物材料的采购，适当的高通量筛选生物测定的选择和实施以及活性化合物的放大。

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