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首页> 外文期刊>Life sciences >Modification of cardiac oxidative stress in alloxan-induced diabetic rabbits with repaglinide treatment
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Modification of cardiac oxidative stress in alloxan-induced diabetic rabbits with repaglinide treatment

机译：瑞格列奈治疗对四氧嘧啶致糖尿病兔心脏氧化应激的改变

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The aim of this study was to analyze the antioxidative effect of repaglinide in the heart of alloxan-induced diabetic rabbits. The activities of superoxide dismutase (Cu,Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R), glutathione (GSH), ascorbic acid (AA), products of lipid peroxidation (LPO) and protein carbonyl groups (PCG) were estimated after 4 and 8 weeks of repaglinide treatment (1 mg daily). At significance level p < 0.05, in diabetic heart the activities of Cu,Zn-SOD and CAT were elevated as compared to control values (by 60.7% and 55.3% for Cu,Zn-SOD, and by 89.7% and 77.4% for CAT after 4 and 8 weeks, respectively). The level of AA was diminished by 52.5% and 41.5% while GSH-Px and GSSG-R activities were decreased after 4 weeks of experiment (by 11.5% and 14.4%, respectively). GSH level was diminished by 33.2% after 8 weeks. Simultaneously, in diabetic heart the levels of LPO and PCG were elevated as compared to control values (by 51.6% and 111.3% for LPO, and by 72.0% and 132.9% for PCG after 4 and 8 weeks, respectively). In diabetic animals, repaglinide normalized GSH-Px activity and GSH level. It modified the activities of Cu,Zn-SOD, CAT and AA as compared to diabetic non-treated animals. In diabetic-treated rabbits the level of LPO was diminished as compared to diabetic non-treated animals, while the level of PCG was not affected. In the present study, repaglinide did not affect blood glucose and plasma insulin concentrations in diabetic rabbits. Nevertheless, the drug showed some beneficial antioxidative properties in the heart tissue. (c) 2005 Elsevier Inc. All rights reserved.
机译：这项研究的目的是分析瑞格列奈在四氧嘧啶诱导的糖尿病兔心脏中的抗氧化作用。超氧化物歧化酶（Cu，Zn-SOD），过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GSH-Px），谷胱甘肽还原酶（GSSG-R），谷胱甘肽（GSH），抗坏血酸（AA），脂质过氧化产物（在瑞格列奈治疗4周和8周（每天1 mg）后，估计LPO）和蛋白羰基（PCG）。在显着性水平p <0.05时，糖尿病心脏中的铜，锌-超氧化物歧化酶和CAT的活性比对照值升高（铜，锌-超氧化物歧化酶分别升高60.7％和55.3％，而CAT分别升高89.7％和77.4％分别在4周和8周后）。实验4周后，AA水平降低了52.5％和41.5％，而GSH-Px和GSSG-R活性降低了（分别降低了11.5％和14.4％）。 8周后GSH水平降低了33.2％。同时，在糖尿病心脏中，与对照组相比，LPO和PCG的水平升高（LPO分别升高51.6％和111.3％，4周和8周后PCG分别升高72.0％和132.9％）。在糖尿病动物中，瑞格列奈可使GSH-Px活性和GSH水平正常化。与未治疗的糖尿病动物相比，它改变了Cu，Zn-SOD，CAT和AA的活性。与糖尿病未治疗的动物相比，在糖尿病治疗的兔子中LPO的水平降低了，而PCG的水平未受到影响。在本研究中，瑞格列奈不影响糖尿病兔的血糖和血浆胰岛素浓度。然而，该药物在心脏组织中显示出一些有益的抗氧化特性。 （c）2005 Elsevier Inc.保留所有权利。

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