首页> 外文期刊>Life sciences >Metoprolol reduces 'compensatory' coronary blood flow following occlusion of an adjacent branch without altering post-occlusion hyperaemia.
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Metoprolol reduces 'compensatory' coronary blood flow following occlusion of an adjacent branch without altering post-occlusion hyperaemia.

机译:美托洛尔减少相邻分支闭塞后的“代偿性”冠状动脉血流,而不会改变闭塞后充血。

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摘要

In pentobarbitone anaesthetised, thoracotomised dogs, blood flow in one (circumflex; LCX) branch of the left coronary artery increases when an adjacent (anterior descending; LAD) branch is occluded. We show that this 'compensatory blood flow' increase results from an enhanced regional myocardial contractility, as assessed using piezoelectric crystals, and that this is to compensate for a marked decrease in segmental shortening (SS) in the region supplied by the occluded vessel. These changes in regional contractility are relatively unaffected by the intravenous administration of metoprolol whereas the LCX flow change is markedly reduced, suggesting a major contribution of coronary vascular beta(1)-adrenoceptors to such 'compensatory' flow changes.
机译:在戊巴比妥麻醉的经胸腔切开的狗中,当相邻(前降; LAD)分支被阻塞时,左冠状动脉的一个(回旋; LCX)分支中的血流量增加。我们显示,这种“代偿性血流量”的增加是由于使用压电晶体评估的区域心肌收缩力增强而引起的,并且这是为了补偿由闭塞血管供应的区域中节段性缩短(SS)的明显减少。这些区域收缩力的变化相对不受美托洛尔静脉内给药的影响,而LCX流量变化显着减少,表明冠状血管β(1)-肾上腺素受体对这种“代偿性”流量变化起主要作用。

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