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首页> 外文期刊>Life sciences >Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats.
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Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats.

机译：姜黄素对四氯化碳诱导的大鼠肝细胞色素P450同工酶失活的选择性保护。

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摘要

We investigated the effects of curcumin, a major antioxidant constituent of turmeric, on hepatic cytochrome P450 (CYP) activity in rats. Wistar rats received curcumin-containing diets (0.05, 0.5 and 5 g/kg diet) with or without injection of carbon tetrachloride (CCl(4)). The hepatic CYP content and activities of six CYP isozymes remained unchanged by curcumin treatment, except for the group treated with the extremely high dose (5 g/kg). This suggested that daily dose of curcumin does not cause CYP-mediated interaction with co-administered drugs. Chronic CCl(4) injection drastically decreased CYP activity, especially CYP2E1 activity, which is involved in the bioactivation of CCl(4), thereby producing reactive free radicals. Treatment with curcumin at 0.5 g/kg alleviated the CCl(4)-induced inactivation of CYPs 1A, 2B, 2C and 3A isozymes, except for CYP2E1. The lack of effect of curcumin on CYP2E1 damage might be related to suicidal radical production by CYP2E1 on the same enzyme. It is speculated that curcumin inhibited CCl(4)-induced secondary hepatic CYPs damage through its antioxidant properties. Our results demonstrated that CYP isozyme inactivation in rat liver caused by CCl(4) was inhibited by curcumin. Dietary intake of curcumin may protect against CCl(4)-induced hepatic CYP inactivation via its antioxidant properties, without inducing hepatic CYPs.
机译：我们研究了姜黄素（姜黄的主要抗氧化剂成分）对大鼠肝细胞色素P450（CYP）活性的影响。 Wistar大鼠接受含姜黄素的饮食（0.05、0.5和5 g / kg饮食），可注射或不注射四氯化碳（CCl（4））。姜黄素治疗组的肝CYP含量和6种CYP同工酶的活性保持不变，但给予极高剂量（5 g / kg）的组除外。这表明姜黄素的每日剂量不会引起CYP介导的与共同给药药物的相互作用。慢性CCl（4）注射会大大降低CYP活性，尤其是CYP2E1活性，这与CCl（4）的生物活化有关，从而产生反应性自由基。以0.5 g / kg的姜黄素治疗可减轻CCl（4）诱导的CYP 1A，2B，2C和3A同工酶的灭活，但CYP2E1除外。姜黄素对CYP2E1损伤的作用缺乏可能与CYP2E1在同一酶上产生自杀自由基有关。据推测，姜黄素通过其抗氧化特性抑制CCl（4）诱导的继发性肝CYPs损伤。我们的研究结果表明姜黄素可抑制CCl（4）引起的大鼠肝脏CYP同工酶失活。饮食中姜黄素的摄入可通过其抗氧化特性防止CCl（4）诱导的肝CYP失活，而不诱导肝CYP。

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